Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA.
Department of Surgery, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Life Sci. 2024 Aug 15;351:122783. doi: 10.1016/j.lfs.2024.122783. Epub 2024 Jun 5.
The increasing global prevalence of chronic wounds underscores the growing importance of developing effective animal models for their study. This review offers a critical evaluation of the strengths and limitations of rat models frequently employed in chronic wound research and proposes potential improvements. It explores these models in the context of key comorbidities, including diabetes, venous and arterial insufficiency, pressure-induced blood flow obstruction, and infections. Additionally, the review examines important wound factors including age, sex, smoking, and the impact of anesthetic and analgesic drugs, acknowledging their substantial effects on research outcomes. A thorough understanding of these variables is crucial for refining animal models and can provide valuable insights for future research endeavors.
慢性伤口在全球的发病率不断上升，这凸显了开发有效动物模型来研究它们的重要性不断增加。本综述批判性地评估了在慢性伤口研究中常用的大鼠模型的优缺点，并提出了潜在的改进方法。它探讨了这些模型在包括糖尿病、静脉和动脉功能不全、压力引起的血流阻塞以及感染等主要合并症中的应用。此外，本综述还研究了重要的伤口因素，包括年龄、性别、吸烟以及麻醉和镇痛药物的影响，认识到这些因素对研究结果有重大影响。深入了解这些变量对于改进动物模型至关重要，并可为未来的研究工作提供有价值的见解。
