Geriatric Education and Research Institute (GERI), 2 Yishun Central 2, Singapore, 768024, Singapore.
Adelaide Medical School, Faculty of Health and Medical Science, The University of Adelaide, Adelaide, South Australia, 5005, Australia.
BMC Geriatr. 2022 Aug 16;22(1):677. doi: 10.1186/s12877-022-03363-2.
Emerging evidence suggest that in addition to low hand grip strength (HGS), HGS asymmetry is associated with declining cognitive and physical functions. We examined the associations of low HGS and asymmetry with cognitive function and functional mobility in older adults.
Cross-sectional data of 330 community-dwelling adults (55.2% women) aged ≥ 55 years included HGS, Repeated Battery for the Assessment of Neuropsychological Status (RBANS), and Timed-Up-and-Go (TUG). Low HGS was defined as < 28 kg for men and < 18 kg for women. Participants with HGS above 10% stronger on either hand were considered as having HGS asymmetry. Multiple linear regression models were adjusted for sociodemographic, smoking, education, comorbidity count, physical activity participation, obesity, self-rated health and hand dominance.
Low HGS, but not asymmetry, was independently associated with lower functional mobility performance (β = 1.3, 95%CI = 0.6,1.9), global cognitive function (β = -10.4, 95%CI = -17.0,-3.8), immediate (β = -2.6, 95%CI = -4.5,-0.7) and delayed (β = -2.8, 95%CI = -5.0,-0.7) memory. Compared to normal and symmetric HGS participants, low HGS in combination with HGS asymmetry was associated with poorer language scores. In participants with normal HGS, asymmetric HGS was associated with slower TUG than corresponding groups with symmetric HGS.
Low HGS, but not asymmetry, was associated with lower cognition and functional mobility. Associations of combined low HGS and asymmetry with cognitive and physical functions were driven by grip strength rather than asymmetry.
新出现的证据表明，除了握力低（HGS）外，HGS 不对称与认知和身体功能下降有关。我们研究了 HGS 降低和不对称与老年人认知功能和功能移动性的关系。
纳入了 330 名年龄在 55 岁及以上的社区居民（55.2%为女性）的横断面数据，包括 HGS、重复性脑力状态评估量表（RBANS）和计时起立行走测试（TUG）。男性 HGS<28kg，女性 HGS<18kg 定义为低 HGS。HGS 较高手强 10%以上的参与者被认为存在 HGS 不对称。多线性回归模型调整了社会人口统计学、吸烟、教育、合并症计数、体育活动参与、肥胖、自我报告健康状况和手优势。
低 HGS，但不是不对称，与较差的功能性移动性表现（β=1.3，95%置信区间：0.6，1.9）、整体认知功能（β=-10.4，95%置信区间：-17.0，-3.8）、即刻（β=-2.6，95%置信区间：-4.5，-0.7）和延迟（β=-2.8，95%置信区间：-5.0，-0.7）记忆独立相关。与 HGS 正常且对称的参与者相比，HGS 降低且不对称与较差的语言评分相关。在 HGS 正常的参与者中，不对称 HGS 与 TUG 比相应的对称 HGS 组更慢。
低 HGS，但不是不对称，与认知和功能移动性降低有关。HGS 降低和不对称与认知和身体功能的关联是由握力而不是不对称驱动的。
