Getz Godfrey S, Reardon Catherine A
Department of Pathology, The University of Chicago, Chicago, IL, United States.
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, United States.
Front Pharmacol. 2019 May 21;10:536. doi: 10.3389/fphar.2019.00536. eCollection 2019.
Macrophages are core cellular elements of both early and advanced atherosclerosis. They take up modified lipoproteins and become lipid-loaded foam cells and secrete factors that influence other cell types in the artery wall involved in atherogenesis. Apoproteins E, AI, and SAA are all found on HDL which can enter the artery wall. In addition, apoE is synthesized by macrophages. These three apoproteins can promote cholesterol efflux from lipid-loaded macrophages and have other functions that modulate macrophage biology. Mimetic peptides based on the sequence or structure of these apoproteins replicate some of these properties and are potential therapeutic agents for the treatment of atherosclerosis to reduce cardiovascular diseases.
巨噬细胞是早期和晚期动脉粥样硬化的核心细胞成分。它们摄取修饰的脂蛋白并变成脂质负载的泡沫细胞，并分泌影响动脉壁中参与动脉粥样硬化形成的其他细胞类型的因子。载脂蛋白E、A-I和血清淀粉样蛋白A都存在于可进入动脉壁的高密度脂蛋白上。此外，载脂蛋白E由巨噬细胞合成。这三种载脂蛋白可促进脂质负载的巨噬细胞中的胆固醇流出，并具有调节巨噬细胞生物学的其他功能。基于这些载脂蛋白的序列或结构的模拟肽复制了其中一些特性，是治疗动脉粥样硬化以减少心血管疾病的潜在治疗剂。
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