Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
J Am Coll Cardiol. 2018 Oct 30;72(18):2166-2180. doi: 10.1016/j.jacc.2018.08.2148.
Macrophages represent one of the most numerous and diverse leukocyte types in the body. Furthermore, they are important regulators and promoters of many cardiovascular disease programs. Their functions range from sensing pathogens to digesting cell debris, modulating inflammation, and producing key cytokines and other regulatory factors throughout the body. Macrophage research has undergone a renaissance in recent years, which has propelled a newfound interest in their heterogeneity as well as a new understanding of ontological differences in their development. In addition, recent technological advances such as single-cell mass-cytometry by time-of-flight have enabled phenotype and functional analyses of individual immune myeloid cells, including macrophages, at unprecedented resolution. In this Part 1 of a 4-part review series covering the macrophage in cardiovascular disease, we focus on the basic principles of macrophage development, heterogeneity, phenotype, tissue-specific differentiation, and functionality as a basis to understand their role in cardiovascular disease.
巨噬细胞是体内数量最多、种类最多的白细胞之一。此外，它们是许多心血管疾病程序的重要调节剂和促进剂。它们的功能范围从感知病原体到消化细胞碎片，调节炎症，以及在全身产生关键的细胞因子和其他调节因子。近年来，巨噬细胞研究经历了一场复兴，这促使人们对其异质性产生了新的兴趣，并对其发育中的本体论差异有了新的认识。此外，单细胞质量细胞仪飞行时间等最近的技术进步使得包括巨噬细胞在内的单个免疫髓样细胞的表型和功能分析能够以前所未有的分辨率进行。在涵盖心血管疾病中巨噬细胞的 4 部分综述系列的第 1 部分中，我们重点介绍了巨噬细胞发育、异质性、表型、组织特异性分化和功能的基本原则，以了解它们在心血管疾病中的作用。
