Tocco-Bradley R, Georgieff M, Jones C T, Moldawer L L, Dinarello C A, Blackburn G L, Bistrian B R
Laboratory of Nutrition and Infection, New England Deaconess Hospital, Boston, Massachusetts.
Eur J Clin Invest. 1987 Dec;17(6):504-10. doi: 10.1111/j.1365-2362.1987.tb01149.x.
Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, and often depend on the causative agent and the stage and severity of the illness. We studied the effect of IL-1, the protein mediator of the 'acute phase' response during infection, on REE, respiratory quotient (RQ), and fat metabolism in male rats (210 g), who were infused over an 8-h period with (1-14C)-palmitate (PALM), (2-3H)-glycerol (GLY) and either saline or interleukin-1 (IL-1). At 7-8 h post infusion, the IL-1 group showed a significant increase in REE but no change in RQ. The IL-1 group also exhibited a significant decrease in serum free fatty acid (FFA) and an increase in FFA clearance. Free fatty acid flux, %PALM oxidation, serum (GLY), glycerol clearance, and glycerol flux (a measure of lipolytic rate) were not significantly different between the two groups. We conclude that IL-1 can mimic the increase in REE seen during infection; the increase in REE is not due to a selective increase in fat oxidation only, although the unchanged RQ and increased REE suggest that there is a proportional increase in net FFA oxidation.
脓毒症期间已注意到与静息能量消耗（REE）和脂肪代谢相关的代谢改变，且这些改变通常取决于病原体以及疾病的阶段和严重程度。我们研究了感染期间“急性期”反应的蛋白质介质白细胞介素-1（IL-1）对雄性大鼠（210克）的REE、呼吸商（RQ）和脂肪代谢的影响，这些大鼠在8小时内输注了（1-¹⁴C）-棕榈酸酯（PALM）、（2-³H）-甘油（GLY）以及生理盐水或白细胞介素-1（IL-1）。输注后7-8小时，IL-1组的REE显著增加，但RQ无变化。IL-1组的血清游离脂肪酸（FFA）也显著降低，FFA清除率增加。两组之间的游离脂肪酸通量、%PALM氧化、血清（GLY）、甘油清除率和甘油通量（脂解速率的一种度量）无显著差异。我们得出结论，IL-1可模拟感染期间所见的REE增加；REE的增加并非仅由于脂肪氧化的选择性增加，尽管RQ不变且REE增加表明净FFA氧化有相应增加。
