School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
School of Chemical Engineering, Sichuan University, Chengdu, 610065, China; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, SAR, China.
Colloids Surf B Biointerfaces. 2019 Sep 1;181:767-777. doi: 10.1016/j.colsurfb.2019.06.038. Epub 2019 Jun 18.
Bone restoration and related infection in bone defect repair remain thorny problems in clinical practice. Herein, a drug-loaded (chlorogenic acid, CGA)/grafted peptide (BFP) hydrogel system supported on a sulfonated polyetheretherketone (SPEEK) surface is constructed to address the problem of large-scale defects and related infections in clinical bone implantation. Briefly, the encapsulated chlorogenic acid is released during hydrogel degradation and can inhibit the growth of bacteria and provide a bacteria-free environment for new bone formation. In vitro experiments and cell adhesion/proliferation evaluation reveal that the chlorogenic acid-sodium alginate-peptide bridging system shows better bioaffinity than the control groups due to the BFP peptide on the surface of the hydrogel. In addition, bacterial experiments suggest that the released chlorogenic acid has excellent antibacterial activity against gram-negative and gram-positive bacteria. Therefore, the hydrogel bridging system has a prospective application in clinical applications for bone repair.
骨缺损修复中的骨修复和相关感染仍然是临床实践中的棘手问题。在此，构建了一种载药（绿原酸，CGA）/接枝肽（BFP）水凝胶系统，该系统支撑在磺化聚醚醚酮（SPEEK）表面上，以解决临床骨植入中大规模缺陷和相关感染的问题。简而言之，包封的绿原酸在水凝胶降解过程中释放出来，可以抑制细菌的生长并为新骨形成提供无细菌的环境。体外实验和细胞黏附和增殖评估表明，由于水凝胶表面的 BFP 肽，绿原酸-海藻酸钠-肽桥接系统比对照组表现出更好的生物亲和力。此外，细菌实验表明，释放的绿原酸对革兰氏阴性和革兰氏阳性菌具有优异的抗菌活性。因此，水凝胶桥接系统在骨修复的临床应用中有很好的应用前景。
