Chang M H, Hsu H Y, Chen C J, Lee C H, Hsu J Y
Department of Pediatrics, National Taiwan University, R.O.C.
J Pediatr Gastroenterol Nutr. 1987 May-Jun;6(3):369-72. doi: 10.1097/00005176-198705000-00011.
A total of 852 healthy Chinese children from 1 month to 14 years of age were investigated for lactose malabsorption using the breath hydrogen test. A lactose load of 2 g/kg was administered to 528 children and 1 g/kg to another 324 children. The incidence of lactose malabsorption was significantly different among various age groups and between the two different lactose dosages. While the incidence of malabsorption increased strikingly from the age of 3 to the age of 5 years, the age effect remained constant after the age of 6 years. The lactose load of 2 g/kg induced a higher incidence of malabsorption in study subjects than 1 g/kg did, and the dose effect increased for those aged below 5 years and decreased above 5 years. Small-intestinal lactase was also studied in 34 children aged from 2 months to 15 years. The lactase activity was highest in children 2 years old or younger, gradually decreasing with increasing age. In conclusion, lactase activity in Chinese children decreases gradually after 3 years of age, a finding that correlates well with the results of the breath hydrogen test.
采用呼气氢试验对852名年龄在1个月至14岁的中国健康儿童进行乳糖吸收不良调查。528名儿童给予2 g/kg的乳糖负荷量，另外324名儿童给予1 g/kg的乳糖负荷量。乳糖吸收不良的发生率在不同年龄组以及两种不同乳糖剂量之间存在显著差异。虽然吸收不良的发生率在3岁至5岁时显著增加，但6岁以后年龄效应保持不变。2 g/kg的乳糖负荷量比1 g/kg在研究对象中引起更高的吸收不良发生率，剂量效应在5岁以下儿童中增加，在5岁以上儿童中降低。还对34名年龄在2个月至15岁的儿童进行了小肠乳糖酶研究。乳糖酶活性在2岁及以下儿童中最高，随年龄增长逐渐降低。总之，中国儿童的乳糖酶活性在3岁后逐渐下降，这一发现与呼气氢试验结果密切相关。
