The incidence of pneumonia (PCP) has been increasing among non-HIV-infected patients. Here, we investigated the clinical characteristics, treatment outcomes, and prognostic factors of PCP in non-HIV-infected patients. Information on clinical characteristics, treatment outcomes, and prognostic factors of PCP patients who were treated at a medical center in northern Taiwan from October 2015 to October 2016 were retrieved from medical records and evaluated. Among the patients with PCP included in the study, 84 were non-HIV-infected and 25 were HIV-infected. Non-HIV-infected patients with PCP had a longer duration between radiographic findings and treatment (<0.001), and a higher rate of hospital-associated PCP (<0.001), hypoxia (0.015), respiratory failure (<0.001), and mortality (0.006) than HIV-infected patients with PCP. Among non-HIV-infected patients, non-survivors had a higher fungal burden (46.2% vs 22.2%, =0.039), higher requirement for adjunctive steroid treatment (94.9% vs 71.1%, 0.011), and higher rate of pneumothorax (17.9% vs 2.2%, 0.038) than survivors. Multiple logistic regression revealed that lymphopenia (odds ratio [OR] =3.24, 95% confidence interval [CI] =1.07-9.79; 0.037), adjunctive steroid use (OR =6.23, 95% CI =1.17-33.14; 0.032), and pneumothorax (OR =10.68, 95% CI =1.00-113.93; 0.050) were significantly associated with increased 60-day mortality among non-HIV-infected PCP patients. Lymphopenia, adjunctive steroid therapy, and pneumothorax were significantly associated with higher mortality in non-HIV-infected patients with PCP.