Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.
School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103, Himachal Pradesh, India.
Antiinflamm Antiallergy Agents Med Chem. 2020;19(3):222-239. doi: 10.2174/1871523018666190625170802.
Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder.
补骨脂素或呋喃香豆素是一种线性三环杂环化合物。补骨脂素为平面、三环化合物，由呋喃环与香豆素部分稠合而成。补骨脂素具有广泛的生物活性，包括细胞毒性、光敏性、杀虫性、抗菌性和抗真菌作用。因此，人们引入了几种结构变化来探索特定位置对生物活性的作用。用于合成补骨脂素骨架的方便方法可分为两部分：（i）从间苯二酚制备三环系统，（ii）完整环系统的外环修饰。此外，尽管补骨脂素已被用于多种用途，但我们在这项工作中主要关注其在治疗银屑病、白癜风和皮肤相关疾病方面的临床应用。
