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一株携带 mcr-1 和 blaCTX-M-15 的广泛耐药性大肠杆菌临床分离株中的新型 。

New Variant of in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying and .

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.

出版信息

Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01757-17. Print 2017 Dec.

DOI:10.1128/AAC.01757-17
PMID:28971871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5700326/
Abstract

A colistin- and carbapenem-resistant clinical isolate was found to carry two plasmid-borne colistin-resistant genes, and the newly identified , and a carbapenemase gene, is a new variant () in the isolate and encodes three amino acid substitutions compared with the original MCR-3. was carried by a Tn-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that may have widely spread.

摘要

临床分离株对黏菌素和碳青霉烯类药物均耐药，该分离株携带两种质粒介导的黏菌素耐药基因 和 ，新鉴定的 ，以及一种碳青霉烯酶基因 ，是该分离株中 （）的一个新变体，与原始 MCR-3 相比，其编码三个氨基酸取代。 在该分离株中的一个可自我转移的 IncP 质粒上的 Tn 样转座子上携带 ，这突出表明 可能已经广泛传播。

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