Liao D, Chen S C, Lo K M, Zhao J, Futaba K, Gregersen H
Department of Clinical Medicine,GIOME Academia,Aarhus University,Aarhus DK-8200, Denmarke-mail:
Department of Surgery,GIOME,4/F, Clinical Sciences Building, Prince of Wales Hospital,Shatin, Hong Konge-mail:
J Biomech Eng. 2019 Sep 1;141(9):0945011-5. doi: 10.1115/1.4044134.
A mechanical approach is needed for understanding anorectal function and defecation. Fecal continence is achieved by several interacting mechanisms including anatomical factors, anorectal sensation, rectal compliance, stool consistency, anal muscle strength, motility, and psychological factors. The balance is easily disturbed, resulting in symptoms such as fecal incontinence and constipation. Novel technologies have been developed in recent years for studying anorectal function. Especially, the Fecobionics device, a simulated feces, has gained attention recently. This facilitates new analysis of anorectal mechanical function. In this study, a theoretical model is developed to analyze anorectal mechanophysiological data generated by the Fecobionics device. Theoretical approaches can enhance future interdisciplinary research for unraveling defecatory function, sensory-motor disorders, and symptoms. This is a step in the direction of personalized treatment for gastrointestinal disorders based on optimized subtyping of anorectal disorders.
理解肛门直肠功能和排便需要一种机械学方法。粪便节制是通过多种相互作用的机制实现的，包括解剖学因素、肛门直肠感觉、直肠顺应性、粪便稠度、肛门肌肉力量、运动性以及心理因素。这种平衡很容易被打破，从而导致大便失禁和便秘等症状。近年来已开发出用于研究肛门直肠功能的新技术。特别是，一种模拟粪便的Fecobionics装置最近受到了关注。这有助于对肛门直肠机械功能进行新的分析。在本研究中，开发了一个理论模型来分析由Fecobionics装置产生的肛门直肠机械生理数据。理论方法可以加强未来跨学科研究，以阐明排便功能、感觉运动障碍和症状。这是朝着基于肛门直肠疾病优化分型的胃肠道疾病个性化治疗方向迈出的一步。
