Department of Laboratory Medicine, School of Tropical Medicine, Kolkata, West Bengal, India.
Department of Tropical Medicine, School of Tropical Medicine, Kolkata, West Bengal, India.
J Med Virol. 2019 Oct;91(10):1873-1876. doi: 10.1002/jmv.25529. Epub 2019 Jul 11.
Dengue is the most common arboviral infection globally, but its pathogenesis is poorly explored. Vascular endothelial growth factor (VEGF) has an essential role in the host defense against viral infection. However, not much information is available regarding its status in dengue patients from the eastern zone of India. In the present investigation, the level of VEGF was investigated for its possible utility as a dengue severity marker. Accordingly, confirmed dengue cases were enrolled during 2016-2018. Serum from all the study subjects was subjected to the standard enzyme-linked immunosorbent assay test for VEGF analysis. In addition, we assessed the association of VEGF to dengue severity. The study revealed that VEGF titers (P < .0001) were significantly increased in severe dengue (SD) patients in contrast to those with a milder form of dengue. An association was obtained between VEGF and increased SGOT (r = 0.517 with P < .0001) while VEGF had a negative correlation with platelets in SD patients (r = -0.331 with P = .001). Enhanced VEGF titers along with decreased platelets had a good association with SD. The investigation revealed that high VEGF titers are novel indicators of dengue severity. However, our results must be verified in a study evaluating a larger number of dengue patients.
登革热是全球最常见的虫媒病毒感染，但对其发病机制的研究还很不完善。血管内皮生长因子（VEGF）在宿主抵抗病毒感染中起着重要作用。然而，关于来自印度东部地区登革热患者的 VEGF 状态的信息却很少。在本研究中，研究了 VEGF 的水平，以探索其作为登革热严重程度标志物的可能性。因此，在 2016-2018 年期间纳入了确诊的登革热病例。对所有研究对象的血清进行了 VEGF 的标准酶联免疫吸附试验分析。此外，我们评估了 VEGF 与登革热严重程度的关系。研究表明，与轻度登革热患者相比，重症登革热（SD）患者的 VEGF 滴度（P<0.0001）显著升高。VEGF 与 SGOT 升高之间存在相关性（r=0.517，P<0.0001），而 VEGF 与 SD 患者的血小板呈负相关（r=-0.331，P=0.001）。增强的 VEGF 滴度和减少的血小板与 SD 有很好的相关性。该研究表明，高 VEGF 滴度是登革热严重程度的新指标。然而，我们的结果必须在评估更多登革热患者的研究中得到验证。
