Singh Jitendra, Dinkar Anju, Atam Virendra, Himanshu D, Gupta Kamlesh Kumar, Usman Kauser, Misra Ravi
Senior Resident.
Assistant Professor, Department of Microbiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh.
J Assoc Physicians India. 2017 May;65(5):42-46.
Dengue fever is caused by mosquito-borne arboviral infection that has become a public health concern globally. Recently, an alarming rise of dengue has also been seen in India. Hence the study was undertaken to know profile of clinical manifestations and laboratory findings during the evolution of dengue fever.
In this study, retrospective data analysis was done in 216 seropositive dengue patients admitted between January to December 2014 in department of medicine at a north Indian care hospital. The tests analyzed were blood counts, serum electrolytes, liver function tests, kidney function tests, chest x-ray and other relevant investigations.
Males were commonly affected and the most exposed age group was found to be18-35 years. The seropositive case rate for dengue was 56% for NS1 antigen and 36% for IgM. There was rural dominancy of cases with a peak in September. Fever was the most common clinical feature followed by headache, myalgia, backache, nausea and abdominal pain. Petechia was most common haemorrhagic manifestation. Common laboratory findings included 89.35% decreased Platelet counts (<100 000/cmm), 67.59% increased hematocrit (>45%) and 58.33% deranged liver function test. There was no reported mortality in dengue.
From prompt and proper treatment could prevent deaths in moderate and severe dengue. Atypical presentations of dengue should be kept in mind so as not to miss the cases. Increased community awareness and vector control measures need to be strengthened during peri-monsoon period to reduce burden of dengue cases.
登革热由蚊媒虫媒病毒感染引起，已成为全球公共卫生问题。最近，印度登革热病例也出现惊人增长。因此开展本研究以了解登革热发热病程中的临床表现和实验室检查结果。
本研究对2014年1月至12月在印度北部一家护理医院内科住院的216例血清学阳性登革热患者进行回顾性数据分析。分析的检查项目包括血细胞计数、血清电解质、肝功能检查、肾功能检查、胸部X线及其他相关检查。
男性受影响更为常见，最易感染年龄组为18 - 35岁。登革热NS1抗原血清学阳性病例率为56%，IgM为36%。病例以农村地区为主，9月达到高峰。发热是最常见的临床特征，其次是头痛、肌痛、背痛、恶心和腹痛。瘀点是最常见的出血表现。常见实验室检查结果包括89.35%血小板计数降低（<100 000/立方毫米）、67.59%血细胞比容升高（>45%）和58.33%肝功能检查异常。登革热无死亡报告。
及时恰当的治疗可预防中重度登革热死亡。应牢记登革热的非典型表现以免漏诊。在季风季节前后需提高社区意识并加强病媒控制措施以减轻登革热病例负担。
