Shin Hannah, Chung Matthew, Rose David Z
Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Department of Neurology, University of South Florida, Tampa, FL, USA.
Neurohospitalist. 2019 Jul;9(3):169-171. doi: 10.1177/1941874418805332. Epub 2018 Oct 15.
Chinese Licorice root "gan zao" () is an ancient, medicinal herb utilized in Traditional Chinese Medicine for its presumably antiulcer, anti-inflammatory, antiviral, antibacterial, and expectorant properties. One of the major biologically active components is glycyrrhizin, which when hydrolyzed to glycyrrhetinic acid in the human body, possesses significant hypertensive effects due to interaction with the enzyme 11-β-hydroxysteroid dehydrogenase-2. Glycyrrhizin and glycyrrhetinic acid also show antithrombotic properties, as orally active, direct inhibitors of blood coagulation factor Xa as well as of thrombin. To our knowledge, this is the first reported case of intracranial hemorrhagic stroke associated with Chinese Licorice Root, and first reported case of cerebral microbleeds (CMB) associated with it as well.
中国甘草“甘草”是一种古老的草药，在传统中医中因其可能具有的抗溃疡、抗炎、抗病毒、抗菌和祛痰特性而被使用。其主要生物活性成分之一是甘草酸，当在人体内水解为甘草次酸时，由于与11-β-羟基类固醇脱氢酶-2相互作用而具有显著的高血压作用。甘草酸和甘草次酸还表现出抗血栓特性，作为口服活性的直接凝血因子Xa和凝血酶抑制剂。据我们所知，这是首例报道的与中国甘草相关的颅内出血性中风病例，也是首例报道的与之相关的脑微出血（CMB）病例。
