Karoutas G, Tsitsopoulos P, Taskos N, Karacostas D, Artemis N, Andreou A, Milonas J, Logothetis J
University Thessaloniki, B. Department of Neurology Agios Dimitrios Hospital, Greece.
Acta Neurochir (Wien). 1987;89(1-2):53-63. doi: 10.1007/BF01406668.
The purpose of this study was to examine the effect of extracorporal collateral circulation (ECCC) between the femoral and the external artery (ECA) on the cerebral circulation, in experimentally induced ischaemia, in rabbits. The animals were divided in four groups. Seven animals (Group A) were used to determine the injection pressure (150-160 mmHg) at the ECA, necessary to achieve collateral circulation between ECA and internal carotid artery (ICA), after occlusion of ICA. Group B (8 rabbits) was the control group for establishing cerebral ischaemia (CI) by a) ligating the common carotid artery bilaterally, b) coagulating the right vertebral artery and c) exsanguinating the animal (removing 28-30 ml of blood). The induced ischaemia was studied by BP and PCO2 monitoring, CBF measurement, videomicroscopy of surface cerebral vessels, and finally macroscopic and microscopic examination of brain sections. In group C (8 animals)-moderate degree of CI-brain circulation improved in all animals after the application of the ECCC, installed at 135 min after the onset of CI. In 10 animals (group D) with severe and prolonged (225 min) CI, ECCC enhanced the brain circulation in eight animals to a variable degree.
本研究的目的是在实验诱导的兔缺血模型中，研究股动脉与颈外动脉（ECA）之间的体外侧支循环（ECCC）对脑循环的影响。将动物分为四组。七只动物（A组）用于确定在颈内动脉（ICA）闭塞后，实现ECA与ICA之间侧支循环所需的ECA注射压力（150 - 160 mmHg）。B组（8只兔）为对照组，通过以下方式建立脑缺血（CI）：a）双侧结扎颈总动脉，b）凝固右侧椎动脉，c）使动物放血（去除28 - 30 ml血液）。通过血压和PCO₂监测、脑血流量测量、脑表面血管的视频显微镜检查，以及最终对脑切片进行宏观和微观检查来研究诱导的缺血情况。在C组（8只动物）中，即中度CI组，在CI发作后135分钟建立ECCC后，所有动物的脑循环均得到改善。在10只患有严重且持续时间长（225分钟）CI的动物（D组）中，ECCC使8只动物的脑循环有不同程度的增强。
