Dictor M, Andersson C
Department of Pathology, University Hospital, Lund, Sweden.
Am J Pathol. 1988 Feb;130(2):411-7.
The histogenesis of Kaposi's sarcoma was investigated by immunohistochemical staining of 20 skin specimens that represented four main histologic stages. The early phase of Stage 1 contained lymphatic-like clefts lined by endothelial cells with thin, discontinuous basement membranes shown by anti-laminin, absent Factor VIII-related antigen reactivity (FVIIIRAg), and only rare staining with dilute Ulex europaeus agglutinin I (UEA-I). In the late phase of Stage 1, the clefts developed into anastomosing, blood-filled channels, and the basement membrane became complete. Endothelial marker reactivities were not definitive, but weak staining with UEA-I and variable staining for FVIIIRAg characterized the spindle cells of Stage 2. However, spindle cells in monomorphic nodules were individually enclosed by immunoreactive laminin. The sequence of events, particularly in light of previous angiographic findings of lymphaticovenous union, suggests a disturbance in lymphaticovenous differentiation in Kaposi's sarcoma. Sclerotic closure of channels unable to maintain competent blood flow may select against lymphendothelial traits in the developing spindle cell nodule.
通过对代表四个主要组织学阶段的20个皮肤标本进行免疫组织化学染色，研究了卡波西肉瘤的组织发生。1期早期包含类似淋巴管的裂隙，其内皮细胞衬里有薄的、不连续的基底膜，抗层粘连蛋白显示出这种情况，缺乏VIII因子相关抗原反应性（FVIIIRAg），并且仅用稀释的欧洲荆豆凝集素I（UEA-I）进行罕见染色。在1期后期，裂隙发展为相互吻合的、充满血液的通道，基底膜变得完整。内皮标志物反应性不明确，但UEA-I的弱阳性染色和FVIIIRAg的可变染色是2期梭形细胞的特征。然而，单形性结节中的梭形细胞被免疫反应性层粘连蛋白单独包裹。这些事件的顺序，特别是鉴于先前淋巴管静脉联合的血管造影结果，提示卡波西肉瘤中淋巴管静脉分化存在紊乱。无法维持正常血流的通道的硬化性闭合可能在发育中的梭形细胞结节中选择不利于淋巴管内皮特征的因素。
