RHO 家族 GTPases 在淋巴瘤生物学中的作用。
RHO Family GTPases in the Biology of Lymphoma.
机构信息
Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cells. 2019 Jun 26;8(7):646. doi: 10.3390/cells8070646.
Abstract
RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical and atypical. Both typical and atypical RHO GTPases are critical transducers of intracellular signaling and have been linked to human cancer. Significantly, both gain-of-function and loss-of-function mutations have been described in human tumors with contradicting roles depending on the cell context. The RAS family of GTPases that also belong to the RAS GTPase superfamily like the RHO GTPases, includes arguably the most frequently mutated genes in human cancers (, , and ) but has been extensively described elsewhere. This review focuses on the role of RHO family GTPases in human lymphoma initiation and progression.
摘要
RHO GTPases 是一类小分子，参与调节属于 RAS GTPase 超家族的几种细胞过程。RHO GTPase 家族包括几个成员，它们进一步分为两个不同的组：典型和非典型。典型和非典型 RHO GTPase 都是细胞内信号转导的关键转换器，与人类癌症有关。重要的是，在人类肿瘤中已经描述了功能获得和功能丧失突变，其作用取决于细胞环境而相互矛盾。RAS GTPase 家族也属于 RAS GTPase 超家族，与 RHO GTPase 一样，包括在人类癌症中最常发生突变的基因（NRAS、HRAS 和 KRAS），但已在其他地方进行了广泛描述。这篇综述重点介绍了 RHO 家族 GTPase 在人类淋巴瘤的发生和进展中的作用。
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