Department of Epidemiology and Health Statistics, School of Health Sciences, Wuhan University, Wuhan 430071, China.
Department of Public Health, Wuhan University of Science and Technology School of Medicine, Wuhan 430081, China.
Int J Environ Res Public Health. 2019 Jun 26;16(13):2259. doi: 10.3390/ijerph16132259.
To explore the health effects of indoor/outdoor carbonaceous compositions in PM on pulmonary function among healthy students living in the local university campus.
Daily peak expiratory flow (PEF) and forced expiratory volume in 1 second (FEV) were measured among 37 healthy students in the morning and evening for four two-week periods. Concurrent concentrations of indoor and outdoor PM (particulate matter with an aerodynamic diameter ≤ 2.5μm), carbonaceous components in PM, ambient temperature, and relative humidity in the study area were also obtained. Mixed-effects model was applied to evaluate the associations between carbonaceous components and lung function. Different lags for the carbonaceous components were investigated.
In single-pollutant model, a 10 μg/m increase of indoor and outdoor EC (elemental carbon) associated with -3.93 (95%: -6.89, -0.97) L/min and -3.21 (95%: -5.67, -0.75) L/min change in evening PEF at lag 0 day, respectively. Also, a 10 μg/m increase of indoor and outdoor POC (primary organic carbon) concentration was significantly associated with -5.82 (95%: -10.82, -0.81) L/min and -7.32 (95%: -12.93, -1.71) L/min change of evening PEF at lag 0 day. After adjusting total mass of PM, indoor EC consistently had a significant adverse impact on evening PEF and FEV at lag3 day and a cumulative effect at lag0-3 day.
This study suggests that carbonaceous components in PM indeed have impacts on pulmonary function among healthy young adults especially on evening PEF. Thus, the local mitigation strategies on pollution are needed.
探讨校园内健康学生的室内/外碳质成分对 PM 中肺功能的影响。
在 4 个为期两周的时间段内，每天早晚分别对 37 名健康学生的最大呼气峰流速（PEF）和 1 秒用力呼气量（FEV）进行测量。同时，还获得了研究区域内室内和室外 PM（空气动力学直径≤2.5μm 的颗粒物）、PM 中的碳质成分、环境温度和相对湿度的浓度。采用混合效应模型评估碳质成分与肺功能之间的关联。研究了碳质成分的不同滞后时间。
在单污染物模型中，室内和室外 EC（元素碳）每增加 10μg/m，傍晚 PEF 分别降低-3.93（95%置信区间：-6.89，-0.97）L/min 和-3.21（95%置信区间：-5.67，-0.75）L/min；室内和室外 POC（一次有机碳）浓度每增加 10μg/m，傍晚 PEF 分别降低-5.82（95%置信区间：-10.82，-0.81）L/min 和-7.32（95%置信区间：-12.93，-1.71）L/min。调整 PM 总质量后，室内 EC 在滞后 3 天对傍晚 PEF 和 FEV 仍有显著的不良影响，且在滞后 0-3 天存在累积效应。
本研究表明，PM 中的碳质成分确实对健康年轻成年人的肺功能，尤其是傍晚 PEF 有影响。因此，需要采取当地的污染缓解策略。
