回到 FGF21 的生物学：新的见解。
Going Back to the Biology of FGF21: New Insights.
机构信息
Institute of Metabolic Sciences and MRC-Metabolic Diseases Unit, University of Cambridge, Cambridge, CB0 0QQ, UK.
MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
出版信息
Trends Endocrinol Metab. 2019 Aug;30(8):491-504. doi: 10.1016/j.tem.2019.05.007. Epub 2019 Jun 24.
Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An improved understanding of the biological role of FGF21 may help to explain why its therapeutic potential in humans has not been fully realized. This review will cover the complexities in FGF21 biology in rodents and humans, with emphasis on its role in protection from central and peripheral facets of obesity.
成纤维细胞生长因子 21（FGF21）是一种在肝脏中高度合成的蛋白质，对多种组织中能量稳态的许多方面发挥着旁分泌和内分泌控制作用。在肥胖症和 2 型糖尿病的临床前模型中，用 FGF21 治疗可改善葡萄糖稳态并促进体重减轻，因此，FGF21 作为治疗人类代谢综合征的治疗剂引起了相当大的关注。对 FGF21 生物学的生物学作用的更好理解可能有助于解释为什么其在人类中的治疗潜力尚未完全实现。本综述将涵盖啮齿动物和人类中 FGF21 生物学的复杂性，并重点介绍其在肥胖症的中枢和外周方面的保护作用。
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