Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy
Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy.
BMJ Support Palliat Care. 2020 Dec;10(4):e35. doi: 10.1136/bmjspcare-2018-001755. Epub 2019 Jun 28.
To investigate whether physical activity (PA) is associated with health-related quality of life (HRQOL) outcomes in multiple myeloma (MM) survivors up to 11 years after diagnosis.
We used data from the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship registry. We included 175 MM survivors diagnosed between 1999 and 2009 as registered by the Netherlands Cancer Registry. Sixty-four per cent (n=112/175) of patients who received the questionnaires, completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-MY20. Patients were classified into two groups: physically active and not physically active patients. Univariable and multivariable linear regression models were used to evaluate associations between PA and HRQOL outcomes.
Physically active patients reported a statistically significant higher global health status/HRQOL (p=0.001), lower fatigue (p=0.002) and fewer side effects of treatments (p=0.001), than not physically active patients. PA was not associated with psychological symptoms (ie, anxiety and depressive symptoms) (anxiety: p=0.139; depressive symptoms: p=0.073). Exploratory analyses performed on the other scales of the EORTC QLQ-C30 indicated statistically significant better outcomes in several functional and symptom subscales for physically active patients.
These findings might contribute to a better understanding of the relationship between PA and disease specific HRQOL aspects in MM survivors. Prospective studies are warranted to further elucidate on the beneficial effects of PA on HRQOL outcomes of MM survivors.
调查多发性骨髓瘤（MM）幸存者在诊断后长达 11 年内，体力活动（PA）是否与健康相关的生活质量（HRQOL）结果相关。
我们使用了来自初始治疗和长期生存评估患者报告结局登记处的数据。我们纳入了 1999 年至 2009 年间由荷兰癌症登记处登记的 175 名 MM 幸存者。接受问卷调查的患者中，有 64%（n=112/175）完成了欧洲癌症研究与治疗组织（EORTC）生活质量核心问卷 30 项（QLQ-C30）和 EORTC 多发性骨髓瘤生活质量问卷 20 项（QLQ-MY20）。患者被分为两组：体力活动患者和非体力活动患者。采用单变量和多变量线性回归模型评估 PA 与 HRQOL 结果之间的关系。
与非体力活动患者相比，体力活动患者报告的总体健康状况/HRQOL 更高（p=0.001）、疲劳感更低（p=0.002）、治疗副作用更少（p=0.001）。PA 与心理症状（即焦虑和抑郁症状）无关（焦虑：p=0.139；抑郁症状：p=0.073）。对 EORTC QLQ-C30 的其他量表进行的探索性分析表明，体力活动患者在几个功能和症状子量表中具有更好的结局。
这些发现可能有助于更好地理解 PA 与 MM 幸存者特定疾病的 HRQOL 方面之间的关系。需要前瞻性研究进一步阐明 PA 对 MM 幸存者 HRQOL 结果的有益影响。
