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[三硝酸甘油酯、长效硝酸酯类药物和硝酸皮贴个体化调整剂量长期用于心绞痛患者的疗效比较评估]

[Comparative evaluation of the effectiveness of individually adjusted doses of trinitrolong, sustac and nitroderm in long-term use in patients with stenocardia].

作者信息

Metelitsa V I, Kokurina E V, Piotrovskiĭ V K, Riabokon' S S, Bochkareva E V

出版信息

Kardiologiia. 1987 Nov;27(11):73-7.

PMID:3125375
Abstract

The efficiency of long-term intermittent use of trinitrolong (TNL) and continuous oral use of sustac (ST) was compared in 44 patients with angina of effort, showing particularly good response to long-acting nitrates, as evidenced by paired bicycle ergometric tests. The efficacy of nitroderm (ND) adhesive tape applied on the skin was also assessed in 10 patients. TNL had better antianginal effect, and allowed a higher stress tolerance level, as compared to ST. ND was inferior to TNL and ST in terms of efficiency, apparently due to rapidly developing tolerance to its antianginal effect.

摘要

在44例劳力性心绞痛患者中比较了长效硝酸甘油(TNL)长期间歇性使用和长效硝酸异山梨酯(ST)持续口服的效果,配对的自行车测力计测试表明这些患者对长效硝酸盐反应特别良好。还对10例患者评估了皮肤贴用硝酸甘油(ND)贴剂的疗效。与ST相比,TNL具有更好的抗心绞痛作用,并能使患者耐受更高的应激水平。就疗效而言,ND不如TNL和ST,这显然是由于其抗心绞痛作用迅速产生耐受性所致。

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