Tashima T, Kitamoto T, Tateishi J, Ogomori K, Nakagaki H
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Virchows Arch A Pathol Anat Histopathol. 1988;412(4):323-7. doi: 10.1007/BF00750258.
To identify amyloid deposits in the anterior pituitary gland, we have immunohistochemical, histochemical and alkaline Congo red staining. The anti-human P component reacted positively with these amyloid deposits, while antisera against prealbumin, AA type amyloid fibril protein and various anterior pituitary hormones were negative. A combination of Congo red and anti-human P component staining was most sensitive and reliable for detection of amyloid in the anterior pituitary glands of 300 randomly autopsied patients. Amyloid deposits increased in parallel with the age of the patients, however, they appeared earlier and more frequently than heretofore reported. Deposition of amyloid was seen initially in the 3rd decade and the positivity rate of amyloid deposits was 73% in the 5th decade. The histochemical characteristics of these pituitary amyloid deposits differed from those of cerebral and systemic deposits, particularly those found in the amyloid of senile systemic amyloidosis.
为了鉴定垂体前叶中的淀粉样沉积物，我们采用了免疫组织化学、组织化学和碱性刚果红染色法。抗人P成分与这些淀粉样沉积物呈阳性反应，而抗前白蛋白、AA型淀粉样纤维蛋白和各种垂体前叶激素的抗血清均为阴性。刚果红和抗人P成分染色相结合，对于检测300例随机尸检患者垂体前叶中的淀粉样物质最为敏感和可靠。淀粉样沉积物随患者年龄增长而增加，然而，它们比以往报道的出现得更早、更频繁。淀粉样沉积物最初在第三个十年出现，在第五个十年淀粉样沉积物的阳性率为73%。这些垂体淀粉样沉积物的组织化学特征不同于脑和全身沉积物，特别是在老年系统性淀粉样变性的淀粉样物质中发现的那些。
