State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Sep;11(5):e1567. doi: 10.1002/wnan.1567. Epub 2019 Jul 1.
Nanomedicine, with its advantages of rapid diagnosis, high sensitivity and high accuracy, has aroused extensive interest of researchers, as the cornerstone of nanomedicine, nanomaterials achieve extra attention and rapid development. Among nanomaterials, quantum dots stand out due to their long fluorescence lifetime and excellent antiphotobleaching performance. At present, quantum dots have been applied to the diagnosis and treatment of diseases and various strategies have been presented to fabricate quantum dots. Microfluidic is one promising strategy since microfluidic device can provide an effective platform for the diagnosis of trace disease markers. In this paper, research progress in the microfluidic synthesis of quantum dots and quantum dot-based nanomedical application is discussed. The classification of quantum dots is firstly introduced, and the researches on quantum dots synthesis based on microfluidic is then mainly described, including the sort, design, preparation of microfluidic synthesis device and its application in synthesis. Nanomedical applications of the quantum dots is especially described and emphasized. The prospects for future development of quantum dots from microfluidic for nanomedical application are finally presented. This article is categorized under: Diagnostic Tools > in vitro Nanoparticle-Based Sensing.
纳米医学具有快速诊断、高灵敏度和高精度的优势,引起了研究人员的广泛兴趣,作为纳米医学的基石,纳米材料得到了更多的关注和快速发展。在纳米材料中,量子点由于其长荧光寿命和优异的抗光漂白性能而脱颖而出。目前,量子点已应用于疾病的诊断和治疗,并且提出了各种策略来制备量子点。微流控是一种很有前途的策略,因为微流控装置可为痕量疾病标志物的诊断提供有效的平台。本文讨论了量子点的微流体制备和基于量子点的纳米医学应用方面的研究进展。本文首先介绍了量子点的分类,然后主要描述了基于微流控的量子点合成研究,包括微流控合成装置的分类、设计、制备及其在合成中的应用。特别描述和强调了量子点在纳米医学中的应用。最后,对微流控用于纳米医学应用的量子点的未来发展前景进行了展望。本文属于以下分类:诊断工具 > 体外基于纳米颗粒的传感。