Hussain Arshad, Ali Iftikhar, Kaleem Waqar Ahmad, Yasmeen Fatima
Dr. Arshad Hussain, MRCP. Department of Medicine & Allied, Northwest General Hospital & Research Centre, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Iftikhar Ali, M.Phil. Department of Pharmacy, University of Swabi, Khyber Pakhtunkhwa, Pakistan., Paraplegic Center, Hayatabad, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Pak J Med Sci. 2019;35(3):591-597. doi: 10.12669/pjms.35.3.7.
To determine the correlation between body mass index (BMI) and lipid profile in patients with Type 2 Diabetes (T2DM) attending a tertiary care hospital in Peshawar.
A total of 305 patients (men, 132; women, 173) with T2DM visiting an Outpatient department in Northwest General Hospital and Research Centre, Peshawar from January 2016 to July 2016 were included in this study. The whole blood and sera were analyzed for Glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TGs), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). The correlation of BMI with lipid ratios and individual lipid indices were analysed.
Mean of BMI was 29.29±5.23. Dyslipidemia; increased TC, increased LDL-C, increased triglyceride and decreased HDL-C were noted in 40.7%, 54.1%, 69.5% and 41% respectively. The mean difference of LDL-C (=0.006) was significant between male and female. BMI, TC, TGs, and LDL-C showed no significant correlation where as a significant negative correlation between BMI and HDL-C was observed (r=-0.125, =0.029, R=0.016). The mean values of TC, TG, LDL-C, TC/ HDL-C and LDL/HDL were greater in patients with normal BMI compared to overweight and obese; however, the differences were not significant. HDL-C differed significantly in BMI groups (p=0.040).
A significant negative correlation between BMI and HDL-C was observed, while the correlation between BMI and LDL-C was observed to be insignificant. HDL-C was found significantly higher in patients with normal BMI. These results are important to indicate that there is modest impact of BMI on lipid profile. Therefore, assessment and management for altered blood lipids should not be based on a patient's body weight or BMI.
确定白沙瓦一家三级护理医院中2型糖尿病（T2DM）患者的体重指数（BMI）与血脂谱之间的相关性。
本研究纳入了2016年1月至2016年7月期间在白沙瓦西北综合医院及研究中心门诊部就诊的305例T2DM患者（男性132例，女性173例）。对全血和血清进行糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）分析。分析BMI与血脂比值和个体血脂指标之间的相关性。
BMI平均值为29.29±5.23。血脂异常；TC升高、LDL-C升高、甘油三酯升高和HDL-C降低的发生率分别为40.7%、54.1%、69.5%和41%。男性和女性之间LDL-C的平均差异（=0.006）具有统计学意义。BMI、TC、TGs和LDL-C之间无显著相关性，而BMI与HDL-C之间存在显著负相关（r=-0.125，=0.029，R=0.016）。与超重和肥胖患者相比，BMI正常的患者TC、TG、LDL-C、TC/HDL-C和LDL/HDL的平均值更高；然而，差异不显著。BMI组间HDL-C差异有统计学意义（p=0.040）。
观察到BMI与HDL-C之间存在显著负相关，而BMI与LDL-C之间的相关性不显著。发现BMI正常的患者HDL-C显著更高。这些结果表明BMI对血脂谱有适度影响，这一点很重要。因此，血脂改变的评估和管理不应基于患者的体重或BMI。
