Jiang Fengru, Ling Xiaofeng
Department of General Surgery, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, P.R.China, 100191, 86-010-82267332.
J Cancer. 2019 May 26;10(11):2407-2414. doi: 10.7150/jca.32411. eCollection 2019.
Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasion and inhibit apoptosis of CCA. Moreover, lncRNA is negatively correlated with the prognosis of CCA. LncRNA may contribute to the development of CCA via modulating gene transcription, sponging microRNA, regulating CCA-related signaling pathways or protein expression. LncRNA is thought to be potential diagnostic markers and therapeutic targets for CCA.
胆管癌（CCA）是一种近年来发病率不断上升的恶性肿瘤。由于缺乏明显症状和特异性诊断标志物，CCA患者通常在晚期才被诊断出来。目前，手术切除是治疗CCA的唯一有效方法，而总体5年生存率仍维持在10%左右。长链非编码RNA（lncRNA）是非编码RNA的一种亚型，已被广泛研究发现在包括CCA在内的多种癌症中异常表达。LncRNA可促进CCA的增殖、迁移、侵袭并抑制其凋亡。此外，lncRNA与CCA的预后呈负相关。LncRNA可能通过调节基因转录、吸附微小RNA、调控与CCA相关的信号通路或蛋白质表达来促进CCA的发展。LncRNA被认为是CCA潜在的诊断标志物和治疗靶点。
