Li Xingwang, Xu Min, Ding Li, Tang Jinhai
School of Clinical Medicine, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, PR China.
Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
J Cancer. 2019 Jun 2;10(12):2836-2848. doi: 10.7150/jca.31361. eCollection 2019.
MicroRNAs (miRNAs) are endogenous, time sequencing, conserved and small non-coding RNA molecules (19-25 bp long) that regulate gene expression at the post-transcriptional level by binding to the partial sequence homology of the 3'-untranslated region of target messenger (m)RNA. The miRNA-27 family consists of miR-27a and miR-27b, which are transcribed from different chromosomes and different in nucleotide at the 3' end. It has been reported that miR-27a was located on chromosome 19 and played a vital role in tumor development. Increasing evidences support a vital role for miR-27a in modulating polymorphisms, tumorigenesis, proliferation, apoptosis, invasion, migration and angiogenesis. Apart from it, miR-27a could affect drug sensitivity, treatment of cancer and patients prognosis. The miR-27a could be an oncogene or a tumor suppressor in several types of cancer, including colon cancer, pancreatic cancer, breast cancer, bladder cancer and hepatocellular carcinoma. In this review, we discuss the role of miR-27a in tumor biology and clinical significance in detail and offer novel insights into molecular targeting therapy for human cancers.
微小RNA（miRNA）是内源性、具有时间序列性、保守的小非编码RNA分子（长度为19 - 25个碱基对），其通过与靶信使（m）RNA的3'非翻译区的部分序列同源性结合，在转录后水平调节基因表达。miRNA - 27家族由miR - 27a和miR - 27b组成，它们从不同染色体转录而来，3'端核苷酸不同。据报道，miR - 27a位于19号染色体上，在肿瘤发展中起重要作用。越来越多的证据支持miR - 27a在调节多态性、肿瘤发生、增殖、凋亡、侵袭、迁移和血管生成中起重要作用。除此之外，miR - 27a可影响药物敏感性、癌症治疗及患者预后。在包括结肠癌、胰腺癌、乳腺癌、膀胱癌和肝细胞癌在内的几种癌症中，miR - 27a可能是一种癌基因或肿瘤抑制基因。在本综述中，我们详细讨论了miR - 27a在肿瘤生物学中的作用及其临床意义，并为人类癌症的分子靶向治疗提供了新的见解。
