Adhvaryu S G, Rawal U M, Patel J V, Patel D D, Balar D B
Department of Cancer Biology, Gujarat Cancer and Research Institute, Ahmedabad, India.
Int J Cancer. 1988 Mar 15;41(3):394-8. doi: 10.1002/ijc.2910410313.
Spontaneous and mitomycin-C (MMC)-induced rates of sister chromatid exchanges (SCEs) were studied in peripheral blood lymphocytes (PBLs) of 40 patients with cancer of the breast and 40 healthy female volunteers as controls. Spontaneous SCE per cell value in PBL cultures was 7.72 for the breast cancer patients, which was significantly higher (p less than 0.001) than the 6.28 SCEs per cell scored for the controls. Eight of the patients were studied a second time, 3 to 6 months following surgical removal of the tumour. A significant (p less than 0.05) reduction in SCE per cell value was observed following mastectomy. MMC-induced frequencies of SCE remained comparable in patients and controls. Cellular kinetics, calculated as average generation time (AGT) from the frequency of cells in M1, M2 and M3 cycles, were comparable in patients and controls.
对40例乳腺癌患者的外周血淋巴细胞（PBL）和40名健康女性志愿者作为对照，研究了自发及丝裂霉素-C（MMC）诱导的姐妹染色单体交换（SCE）率。乳腺癌患者PBL培养物中每细胞的自发SCE值为7.72，显著高于对照组每细胞6.28次SCE（p<0.001）。8例患者在手术切除肿瘤后3至6个月进行了第二次研究。乳房切除术后观察到每细胞SCE值显著降低（p<0.05）。患者和对照组中MMC诱导的SCE频率保持相当。根据M1、M2和M3周期中细胞频率计算的细胞动力学，以平均世代时间（AGT）表示，患者和对照组相当。
