Lam A M, Parkin J A
Can Anaesth Soc J. 1981 Sep;28(5):450-2. doi: 10.1007/BF03010354.
A case of prolonged post-operative somnolence is described. The patient was on concurrent benzodiazepine and cimetidine therapy. Cimetidine can cause impairment of metabolism of the benzodiazepines by inhibiting the hepatic microsomal enzyme system and its possible role in causing the prolonged somnolence is discussed.
描述了一例术后长期嗜睡的病例。该患者同时接受苯二氮䓬类药物和西咪替丁治疗。西咪替丁可通过抑制肝微粒体酶系统导致苯二氮䓬类药物代谢受损,并讨论了其在导致长期嗜睡中可能的作用。