Zhang Yu, Liu Bin, Zhao Ranzun, Zhang Saidan, Yu Xi-Yong, Li Yangxin
Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215123, Jiangsu, People's Republic of China.
Department of Cardiology, the First Hospital of Jilin University, Changchun, 130041, Jilin, People's Republic of China.
J Cardiovasc Transl Res. 2020 Feb;13(1):3-13. doi: 10.1007/s12265-019-09898-x. Epub 2019 Jul 1.
Cardiovascular disease (CVD) is the leading cause of death world-wide. Most of treatment strategies were based on studies conducted on male patients. Studies have shown that significant differences exist between the two sexes in the development of CVD. There are certain differences between men and women in the structure and physiological functions of the heart such as left ventricular mass index, resting heart rate, and contractile function. Accordingly, the pathological features of the heart such as the extend of hypertrophy, fibrosis, and remodeling are also different. In addition, different genders also affect clinical symptoms, responses to treatment and prognosis in the development of CVD. Therefore, it is important to take these differences into consideration when design treatment options for men and women.
心血管疾病（CVD）是全球主要的死亡原因。大多数治疗策略是基于对男性患者进行的研究。研究表明，在心血管疾病的发展方面，两性之间存在显著差异。男性和女性在心脏的结构和生理功能方面存在某些差异，如左心室质量指数、静息心率和收缩功能。因此，心脏的病理特征，如肥大、纤维化和重塑的程度也有所不同。此外，不同性别也会影响心血管疾病发展过程中的临床症状、对治疗的反应和预后。因此，在为男性和女性设计治疗方案时考虑这些差异很重要。
