Byrom N A, Timlin D M
Br J Dermatol. 1979 May;100(5):491-8. doi: 10.1111/j.1365-2133.1979.tb05574.x.
We have searched the literature for data on the in vitro assessment of immune status in atopic eczema patients, and have found much confusion. The major findings are tabulated. It is concluded that atopic eczema is a form of immune deficiency, although it is unclear whether this is a primary or secondary defect. Most authors find a T-lymphocyte deficit while eosinophils, B lymphocytes and serum IgE are increased. Serum IgE levels appear to correlated with severity of eczema symptoms. We have previously suggested that T-lymphocyte levels are overestimated in eczema when fetal calf serum is used in the E-rosette assay. Analysis of the literature for the effect of this serum in the assay confirms that there is a T-lymphocyte deficit in atopic eczema, but that the serum masks it. Thus, much of the confusion surrounding this issue can be resolved.
我们检索了文献，以查找有关特应性皮炎患者免疫状态体外评估的数据，结果发现存在很多混淆之处。主要研究结果已列成表格。得出的结论是，特应性皮炎是一种免疫缺陷形式，尽管尚不清楚这是原发性还是继发性缺陷。大多数作者发现T淋巴细胞缺乏，而嗜酸性粒细胞、B淋巴细胞和血清IgE增加。血清IgE水平似乎与湿疹症状的严重程度相关。我们之前曾提出，在E花环试验中使用胎牛血清时，湿疹患者的T淋巴细胞水平被高估了。对该血清在试验中的作用的文献分析证实，特应性皮炎存在T淋巴细胞缺乏，但血清掩盖了这一情况。因此，围绕这个问题的许多混淆之处可以得到解决。
