Laboratory of Pesticide Residues and Environmental Toxicology, School of Chemistry and Biological Engineering School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China.
Regul Toxicol Pharmacol. 2019 Oct;107:104416. doi: 10.1016/j.yrtph.2019.104416. Epub 2019 Jun 29.
Dietary risk assessment generally combines food consumption data and the concentration of pesticide by using the risk quotient (RQ) method. Chlorothalonil is the second popular fungicide in the world, and its residue and risk assessment in water spinach remain unknown. In this paper, the field trials of chlorothalonil in water spinach were operated under good agricultural practice (GAP) in China to human health protective. The dissipation experiments demonstrated that chlorothalonil was rapidly degraded in water spinach, with the half-lives of 1.8-3.2 days, and the amount of its metabolite SDS-3701 (4-hydroxy-2,5,6-trichloroisophthalonitrile) taken up through the water spinach roots from the soil was minor. The terminal experiments disclosed that the average residues of chlorothalonil and SDS-3701 in water spinach were below 6.59 mg/kg and 0.01 mg/kg, respectively. The results suggested the chronic dietary risk probability of chlorothalonil was 51.95-59.15% in terms of all registered crops, and the acute dietary risk probability of chlorothalonil was 12.30%-63.01% in water spinach, highlighting that the dietary risk of chlorothalonil in water spinach under GAP was acceptable. MRL of chlorothalonil was proposed as 7 mg/kg for water spinach and 5 days was recommended as a safe pre-harvest interval (PHI) for chlorothalonil application in water spinach field.
膳食风险评估通常结合食物消费数据和农药浓度，使用风险商数（RQ）方法。百菌清是世界上第二大受欢迎的杀菌剂，其在蕹菜中的残留和风险评估尚不清楚。本文在中国良好农业规范（GAP）下进行了蕹菜中百菌清的田间试验，以保护人类健康。消解实验表明，百菌清在蕹菜中迅速降解，半衰期为 1.8-3.2 天，其代谢物 SDS-3701（4-羟基-2,5,6-三氯异邻苯二腈）通过蕹菜根系从土壤中摄取的量较小。终期实验表明，蕹菜中百菌清和 SDS-3701 的平均残留量分别低于 6.59mg/kg 和 0.01mg/kg。结果表明，从所有已登记作物的角度来看，百菌清慢性膳食风险概率为 51.95-59.15%，水蕹菜中百菌清的急性膳食风险概率为 12.30%-63.01%，这突出表明 GAP 下水蕹菜中百菌清的膳食风险是可以接受的。建议百菌清在蕹菜中的最大残留限量为 7mg/kg，安全间隔期为 5 天。
