Liu Jun, Yang Lili, Liu Kexin, Gao Feng
Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, China.
Department of Spinal Surgery, The Second Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2023 Feb 13;14:1050954. doi: 10.3389/fphar.2023.1050954. eCollection 2023.
Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.
骨组织工程（BTE）已成为治疗大型骨缺损（包括骨肿瘤、创伤和大面积骨折）的一种有前景的潜在治疗策略，因为在这些情况下骨的自我修复特性无法修复缺损。骨组织工程由三个主要要素组成：祖细胞/干细胞、支架和生长因子/生化信号。在各种生物材料支架中，水凝胶因其生物相容性、可控的力学特性、骨传导性和骨诱导性而被广泛应用于骨组织工程。在骨组织工程过程中，血管生成在骨重建的成败中起着核心作用，它能排出废物并为受损的微环境提供氧气、矿物质、营养物质和生长因子。本文综述了骨组织工程及其要求、水凝胶结构与表征、水凝胶在骨再生中的应用以及水凝胶在骨组织工程过程中对骨血管生成的重要作用。
