Department of Biochemistry, Molecular Biology and Biophysics, Biotechnology Institute, University of Minnesota, Minneapolis, MN, USA.
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
EMBO Rep. 2019 Aug;20(8):e48577. doi: 10.15252/embr.201948577. Epub 2019 Jul 1.
In most animals, sexual reproduction results in a 1:1 ratio of females to males. For several sectors of agriculture, for example, milk or egg production, only a single sex is needed. Biasing the sex ratio so that only offspring of the desired sex are produced has the potential to increase breeding efficiency. In this issue of EMBO Reports, Yosef et al [1] demonstrate a genetic approach to bias the sex ratio in mice by specifically disrupting essential genes in male embryos. Their approach is an important first step toward generating sex-ratio biasing applications for agriculture.
在大多数动物中，有性繁殖的结果是雌性与雄性的比例为 1:1。例如，对于农业的一些领域，如牛奶或鸡蛋生产，只需要单一性别。使性别比例偏向于只产生所需性别的后代具有提高繁殖效率的潜力。在本期的《EMBO 报告》中，Yosef 等人[1]展示了一种通过特异性破坏雄性胚胎中必需基因来偏向小鼠性别比例的遗传方法。他们的方法是朝着为农业生成性别比例偏向应用迈出的重要第一步。
