Openlab "Gene and Cell Technologies", Kazan Federal University, Kazan 420008, the Republic of Tatarstan, Russia.
University Kazan Clinic, Kazan Federal University, Kazan 420008, the Republic of Tatarstan, Russian.
Viruses. 2019 Jul 2;11(7):601. doi: 10.3390/v11070601.
Hemorrhagic fever with renal syndrome (HFRS) is endemic in Tatarstan, where thousands of cases are registered annually. is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. The pathogenesis of HFRS is still not well described, although the cytokine storm hypothesis is largely accepted. In this study, we present a comprehensive analysis of a fatal HFRS case compared with twenty four non-fatal cases where activation of the humoral and cellular immune responses, pro-inflammatory cytokines and disturbed blood coagulation were detected using immunological, histological, genetic and clinical approaches. Multiple organ failure combined with disseminated intravascular coagulation syndrome and acute renal failure was the cause of death. Decreased Interleukin (IL)-7 and increased IL-18, chemokine (C-C motif) ligand (CCL)-5, stem cell growth factor (SCGF)-b and tumor necrosis factor-beta (TNF-β) serum levels were found, supporting the cytokine storm hypothesis of hantavirus pathogenesis.
肾综合征出血热（HFRS）在鞑靼斯坦流行，每年都有数千例病例登记。该病毒在人类病例样本以及被捕的田鼠等啮齿动物宿主中均有发现。HFRS 的发病机制尚未得到很好的描述，尽管细胞因子风暴假说已被广泛接受。在这项研究中，我们对一例致命性 HFRS 病例与 24 例非致命性病例进行了综合分析，通过免疫、组织学、遗传学和临床方法检测到体液和细胞免疫反应、促炎细胞因子和凝血紊乱的激活。多器官衰竭、弥散性血管内凝血综合征和急性肾功能衰竭是死亡的原因。发现白细胞介素（IL）-7 降低和 IL-18、趋化因子（C-C 基序）配体（CCL）-5、干细胞生长因子（SCGF）-b 和肿瘤坏死因子-β（TNF-β）血清水平升高，支持汉坦病毒发病机制的细胞因子风暴假说。
