尿簇集蛋白在流行性肾病中上调。
Urinary Clusterin Is Upregulated in Nephropathia Epidemica.
机构信息
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, Russia.
Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
出版信息
Dis Markers. 2018 Feb 26;2018:8658507. doi: 10.1155/2018/8658507. eCollection 2018.
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine. Furthermore, increased clusterin levels were found in early- and late-phase NE urine. Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine.
肾功能不全是流行性肾病（NE）的标志。目前对 NE 肾脏病理学的机制知之甚少，主要基于尸检组织的发现。我们使用 Bio-Plex 肾脏毒性面板 1 和 2 分析了早期和晚期 NE 尿液中肾脏损伤生物标志物。为了确定疾病的特异性，还分析了痛风、2 型糖尿病、系统性红斑狼疮和慢性肾功能不全患者尿液样本中的肾脏损伤生物标志物。对 12 种生物标志物的分析表明，NE 发病时近端肾小管受损。此外，还检测到 NE 尿液中炎症和白细胞趋化性生物标志物的上调。此外，在早期和晚期 NE 尿液中发现了更高水平的簇蛋白。比较分析表明，簇蛋白是 NE 尿液中上调的生物标志物。
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