Department of Medical Oncology, Ege University School of Medicine, Bornova, Turkey.
Department of Internal Medicine, Ege University School of Medicine, Bornova, Turkey.
Nutr Cancer. 2020;72(2):202-208. doi: 10.1080/01635581.2019.1634217. Epub 2019 Jul 4.
The purpose of this study was to identify the nutritional and performance status of Pancreatic Cancer (PanCa) patients and to determine the relationship between these parameters and their survival time. Ninety-six PanCa patients [59.6% F, 61.4% M; mean age: 60.7 (min:28, max:80) years] were followed up for 6-24 months. The Patient Generated Subjective Global Assessment (PG-SGA) and Eastern Comparative Oncology Group (ECOG) scale were performed. Anthropometric measurements [height, weight, mid-upper arm circumference (MUAC), calf circumference (CC) and triceps skin fold thickness (TSF)], hand grip strength (HGS) were recorded. Survival analyses were conducted using Kaplan-Meier curves. Malnutrition was observed in 85.5% ( = 82) and 54.2% of all patients had poor performance status. A positive correlation was observed between malnutrition and ECOG scale of the patients ( < .01). Antropometric measurements for women and men, respectively, were 34.4 ± 3.03-34.6 ± 3.43 cm for CC; 26.9 ± 3.47-26.05 ± 3.37 cm for MUAC; 20.5 ± 6.3-13.02 ± 7.7 mm for TSF; - 31.02 ± 7.64-20.13 ± 6.04 kg for HGS. Survival time of patients with SGA-A and B was 38.0 ± 6.6 months and of those with SGA-C was 12.0 ± 3.1 months ( = .000). Malnutrition negatively affected both performance status and survival time among PanCa patients.
本研究旨在确定胰腺癌(PanCa)患者的营养和体能状况,并确定这些参数与他们的生存时间之间的关系。对 96 名 PanCa 患者[59.6%女性,61.4%男性;平均年龄:60.7(最小:28,最大:80)岁]进行了 6-24 个月的随访。进行了患者主观整体评估(PG-SGA)和东部肿瘤协作组(ECOG)量表评估。记录了人体测量学测量值[身高、体重、中上臂围(MUAC)、小腿围(CC)和三头肌皮褶厚度(TSF)]、手握力(HGS)。使用 Kaplan-Meier 曲线进行生存分析。观察到 85.5%(=82)的患者存在营养不良,54.2%的患者体能状态较差。营养不良与患者的 ECOG 量表呈正相关( < .01)。女性和男性的人体测量学测量值分别为:CC 为 34.4 ± 3.03-34.6 ± 3.43 cm;MUAC 为 26.9 ± 3.47-26.05 ± 3.37 cm;TSF 为 20.5 ± 6.3-13.02 ± 7.7 mm;HGS 为 - 31.02 ± 7.64-20.13 ± 6.04 kg。SGA-A 和 B 的患者生存时间为 38.0 ± 6.6 个月,SGA-C 的患者为 12.0 ± 3.1 个月( = .000)。营养不良对 PanCa 患者的体能状态和生存时间均有负面影响。