夜班与血糖水平之间关联的结构方程模型
Structural equation modeling of associations between night work and glycemic levels.
作者信息
Silva-Costa Aline, Rotenberg Lúcia, Baltar Valéria Troncoso, Coeli Claudia Medina, Fonseca Maria de Jesus Mendes da, Melo Enirtes Caetano Prates, Griep Rosane Härter
机构信息
Departamento de Saúde Coletiva , Universidade Federal do Triângulo Mineiro (UFTM), Uberaba , MG , Brasil.
Departamento de Epidemiologia e Métodos Quantitativos em Saúde , Escola Nacional de Saúde Pública (ENSP- Fiocruz ), Rio de Janeiro , RJ , Brasil.
出版信息
Arch Endocrinol Metab. 2019 Jun 27;63(5):487-494. doi: 10.20945/2359-3997000000147. eCollection 2019.
OBJECTIVE
Different pathways may lead from night work to metabolic diseases, including type 2 diabetes. This study aimed to explore the direct and indirect pathways from night work to glycemic levels, considering the role of physical activity, waist circumference and snacking using data from ELSA-Brasil.
MATERIALS AND METHODS
A structural equation model was used to confirm the pathways from night work to glycemic levels. The latent variable, "glycemic levels", included fasting glucose, glycated hemoglobin and 2-hour plasma glucose.
RESULTS
A total of 10.396 participants were included in the analyses. The final model showed that among women, night work was associated with increased glycemic levels. A statistical significant association between night work and glycemic levels mediated by waist circumference was observed among women and men.
CONCLUSIONS
The association between night shift and glycemic levels can be interpreted as an important step toward understanding the pathways that could explain night work as a risk factor for diabetes using epidemiological data.
目的
不同途径可能导致夜班工作引发代谢性疾病，包括2型糖尿病。本研究旨在利用巴西老年健康与生活方式研究（ELSA-Brasil）的数据，探讨从夜班工作到血糖水平的直接和间接途径，同时考虑身体活动、腰围和吃零食的作用。
材料与方法
采用结构方程模型来确定从夜班工作到血糖水平的途径。潜在变量“血糖水平”包括空腹血糖、糖化血红蛋白和餐后2小时血糖。
结果
共有10396名参与者纳入分析。最终模型显示，在女性中，夜班工作与血糖水平升高有关。在男性和女性中均观察到夜班工作与通过腰围介导的血糖水平之间存在统计学显著关联。
结论
夜班工作与血糖水平之间的关联可被视为朝着利用流行病学数据理解那些可将夜班工作解释为糖尿病危险因素的途径迈出的重要一步。
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