促甲状腺激素释放激素及其类似物在大鼠体内的产热作用。
Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat.
作者信息
Griffiths E C, Rothwell N J, Stock M J
机构信息
Department of Physiological Sciences, University of Manchester Medical School, England.
出版信息
Experientia. 1988 Jan 15;44(1):40-2. doi: 10.1007/BF01960238.
PMID:3127235
Abstract
Acute or chronic injection of RX 77,368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain. Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO2. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat.
摘要
急性或慢性注射RX 77,368（一种促甲状腺激素释放激素类似物；1毫克/千克，皮下注射）可刺激大鼠的耗氧量（VO2）和棕色脂肪组织活性，并减少体重增加。其他促甲状腺激素释放激素类似物（CG 3509、RGH 2202）以及促甲状腺激素本身也能刺激VO2。这些产热作用可能是通过刺激交感神经向棕色脂肪的输出而在中枢介导的。
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