促甲状腺激素释放激素诱导的小鼠体温过高：肾上腺和垂体可能参与其中。
Thyrotropin releasing hormone-induced hyperthermia in mice: possible involvement of adrenal and pituitary glands.
作者信息
Boschi G, Nomoto T, Rips R
出版信息
Br J Pharmacol. 1983 Oct;80(2):229-33. doi: 10.1111/j.1476-5381.1983.tb10024.x.
To investigate the hyperthermic effect of thyrotropin releasing hormone (TRH) and its potentiation by exogenous catecholamines (CA), the role of the adrenal medulla and of the pituitary gland was studied in unoperated, adrenal-demedullated or hypophysectomized mice. In unoperated mice, TRH 40 mg kg-1 i.p. produced a hyperthermia which was accompanied by an increase in plasma noradrenaline (NA) and adrenaline (Ad). NA or Ad, both at a dose of 1 mg kg-1 i.p., enhanced the TRH-induced hyperthermia. Adrenal demedullation suppressed the hyperthermia and the increase of plasma CA produced by TRH but not the potentiation of this hyperthermia by exogenous CA. Hypophysectomy abolished the TRH-induced hyperthermia but not the increase of plasma CA or the potentiation of this hyperthermia by exogenous CA. These results suggest that, in mice, both the adrenal medulla and the pituitary gland play an essential role in TRH-induced hyperthermia but not in its potentiation.
为了研究促甲状腺激素释放激素（TRH）的热效应及其被外源性儿茶酚胺（CA）增强的作用，我们在未手术、肾上腺髓质切除或垂体切除的小鼠中研究了肾上腺髓质和垂体的作用。在未手术的小鼠中，腹腔注射40 mg/kg的TRH会引起体温升高，同时血浆去甲肾上腺素（NA）和肾上腺素（Ad）增加。腹腔注射剂量为1 mg/kg的NA或Ad均可增强TRH诱导的体温升高。肾上腺髓质切除抑制了TRH引起的体温升高和血浆CA的增加，但不影响外源性CA对该体温升高的增强作用。垂体切除消除了TRH诱导的体温升高，但不影响血浆CA的增加或外源性CA对该体温升高的增强作用。这些结果表明，在小鼠中，肾上腺髓质和垂体在TRH诱导的体温升高过程中都起着重要作用，但在其增强过程中并非如此。
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