Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Cardiology, The Royal Children's Hospital, Parkville, Victoria, Australia.
BMJ Open. 2019 Jul 4;9(Suppl 3):34-43. doi: 10.1136/bmjopen-2017-020896.
To describe the epidemiology and parent-child concordance of vascular function in a population-based sample of Australian parent-child dyads at child age 11-12 years.
Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC).
Assessment centres in seven major Australian cities and eight regional towns or home visits, February 2015-March 2016.
Of all participating CheckPoint families (n=1874), 1840 children (49% girls) and 1802 parents (88% mothers) provided vascular function data. Survey weights and methods were applied to account for LSAC's complex sample design and clustering within postcodes and strata.
The SphygmoCor XCEL assessed vascular function, generating estimates of brachial and central systolic blood pressure and diastolic blood pressure, central pulse pressure, augmentation index and carotid-femoral pulse wave velocity. Pearson's correlation coefficients and multivariable linear regression models estimated parent-child concordance.
Hypertension was present in 3.9% of children and 9.0% of parents. Mean child and parent values for augmentation index were 4.5% (SD 11.6) and 21.3% (SD 12.3), respectively, and those for carotid-femoral pulse wave velocity were 4.48 m/s (SD 0.59) and 6.85 m/s (SD 1.14), respectively. Parent-child correlation for brachial systolic blood pressure was 0.20 (95% CI 0.15 to 0.24), brachial diastolic blood pressure 0.21 (95% CI 0.16 to 0.26), central systolic blood pressure 0.21 (95% CI 0.16 to 0.25), central diastolic blood pressure 0.21 (95% CI0.17 to 0.26), central pulse pressure 0.19 (95% CI 0.14 to 0.24), augmentation index 0.28 (95% CI 0.23 to 0.32) and pulse wave velocity 0.22 (95% CI 0.18 to 0.27).
We report Australian values for traditional and more novel vascular function markers, providing a reference for future population studies. Cross-generational concordance in multiple vascular function markers is already established by age 11-12 years, with mechanisms of heritability remaining to be explored.
描述澳大利亚亲子对子代血管功能的流行病学和亲子一致性，研究对象为 11-12 岁的亲子群体。
横断面研究（儿童健康检查点），嵌套于前瞻性队列研究（澳大利亚儿童纵向研究）。
澳大利亚七个主要城市和八个区域城镇的评估中心，或家庭访问，2015 年 2 月至 2016 年 3 月。
所有参与检查点的家庭（n=1874）中，有 1840 名儿童（49%为女孩）和 1802 名家长（88%为母亲）提供了血管功能数据。调查权重和方法适用于 LSAC 的复杂样本设计以及邮政编码和层次内的聚类。
3.9%的儿童和 9.0%的家长患有高血压。儿童和家长的平均动脉增强指数分别为 4.5%（SD 11.6）和 21.3%（SD 12.3），颈动脉-股动脉脉搏波速度分别为 4.48 m/s（SD 0.59）和 6.85 m/s（SD 1.14）。肱动脉收缩压的亲子相关性为 0.20（95%置信区间为 0.15 至 0.24），肱动脉舒张压为 0.21（95%置信区间为 0.16 至 0.26），中心收缩压为 0.21（95%置信区间为 0.16 至 0.25），中心舒张压为 0.21（95%置信区间为 0.17 至 0.26），中心脉压为 0.19（95%置信区间为 0.14 至 0.24），增强指数为 0.28（95%置信区间为 0.23 至 0.32），脉搏波速度为 0.22（95%置信区间为 0.18 至 0.27）。
我们报告了澳大利亚传统和更新型血管功能标志物的数值，为未来的人群研究提供了参考。11-12 岁时，多个血管功能标志物已经存在跨代的一致性，其遗传机制仍有待探索。
