Ysbyty Gwynedd, Penrhosgarnedd, Bangor, Gwynedd, LL57 2PW, UK.
The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, UK.
Support Care Cancer. 2020 Mar;28(3):1469-1479. doi: 10.1007/s00520-019-04945-4. Epub 2019 Jul 4.
Patients undergoing systemic anti-cancer treatment experience distressing side effects, and these symptoms are often experienced outside the hospital setting. The impact of usage of cancer-related mobile health (mHealth) applications on patient-related outcomes requires investigation.
A critical appraisal of the literature was performed for the following question: 'In patients with cancer have mHealth applications been compared with usual care to examine impact on commonly used clinical outcomes'. Literature searches were undertaken with the help of a research librarian and included Medline, Cochrane Collaboration, clinical trial databases and grey searches.
Seventeen studies including between 12 and 2352 patients were identified and reviewed. Smartphone applications or internet portals collected data on symptoms or patient activity. Several studies showed statistically significant differences in patient-reported outcomes when symptom monitoring using mobile health application was compared to usual care. Change in mobility was the only outcome that was related directly to toxicity. Only limited data on mortality, cancer-related morbidity including complications of care, health-economic outcomes or long-term outcomes were reported.
Studies on mHealth applications might improve aspects of symptom control in patients with cancer, but there is currently little evidence for impact on other outcomes. This requires future research in interventional studies.
接受全身性抗癌治疗的患者会经历令人痛苦的副作用，而且这些症状通常发生在医院环境之外。需要调查使用与癌症相关的移动医疗（mHealth）应用程序对患者相关结果的影响。
在以下问题上对文献进行了批判性评估：“在癌症患者中，mHealth 应用程序是否与常规护理进行了比较，以检查对常用临床结果的影响”。在研究图书馆员的帮助下进行了文献检索，包括 Medline、Cochrane 协作、临床试验数据库和灰色搜索。
确定并审查了 17 项研究，这些研究包括 12 至 2352 名患者。智能手机应用程序或互联网门户收集有关症状或患者活动的数据。几项研究表明，与常规护理相比，使用移动健康应用程序进行症状监测时，患者报告的结果存在统计学上的显著差异。移动性的变化是唯一与毒性直接相关的结果。仅报告了有限的数据，涉及死亡率、癌症相关发病率（包括护理并发症）、健康经济学结果或长期结果。
mHealth 应用程序的研究可能会改善癌症患者的症状控制方面，但目前几乎没有证据表明对其他结果有影响。这需要在干预性研究中进行未来的研究。
