Monleón Santiago, Duque Aránzazu, Mesa-Gresa Patricia, Redolat Rosa, Vinader-Caerols Concepción
Department of Psychobiology, University of Valencia, Valencia, Spain.
Universidad Internacional de Valencia, Valencia, Spain.
Methods Mol Biol. 2019;2011:281-293. doi: 10.1007/978-1-4939-9554-7_16.
Binge drinking (BD), characterized by intermittent consumption of large quantities of alcohol in short periods of time, is the main alcohol consumption pattern in adolescents and young adults. BD has serious biomedical consequences, and it is a prominent risk factor for later development of alcohol use disorders. Rodent models offer exceptional power to study these negative consequences of BD. This chapter focuses on one of these BD models: the chronic-intermittent ethanol administration (CIEA) paradigm. Essentially, CIEA consists of the administration in rats or mice of i.p. injections of ethanol (doses: 3-4 g/kg) for several consecutive days each week, in alternation with several days without injections, during several weeks. Due to our interest in the neurobehavioral effects of BD, a combination of the CIEA model with a battery of behavioral tests is described, with emphasis on the effects of alcohol BD on different kinds of memory. The CIEA model, in combination with behavioral tasks, seems to be a useful tool for studying the neurobehavioral effects of BD as well as for developing potential prevention and treatment strategies.
暴饮（BD）的特征是在短时间内间歇性大量饮酒，是青少年和青年成年人主要的饮酒模式。暴饮会产生严重的生物医学后果，是日后发展为酒精使用障碍的一个突出风险因素。啮齿动物模型为研究暴饮的这些负面后果提供了独特的优势。本章重点介绍其中一种暴饮模型：慢性间歇性乙醇给药（CIEA）范式。从本质上讲，CIEA是每周连续几天给大鼠或小鼠腹腔注射乙醇（剂量：3 - 4克/千克），期间穿插几天不注射，持续数周。由于我们对暴饮的神经行为效应感兴趣，本文描述了CIEA模型与一系列行为测试的结合，重点是酒精暴饮对不同类型记忆的影响。CIEA模型与行为任务相结合，似乎是研究暴饮的神经行为效应以及制定潜在预防和治疗策略的有用工具。
