局部应用（±）r-7，t-8-二羟基-t-9，10-环氧-7，8，9，10-四氢苯并（a）芘和（±）苯并（a）芘-4，5-氧化物后小鼠和大鼠表皮与真皮中DNA加合物的比较。
Comparison of DNA adducts in mouse and rat epidermis versus dermis after topical application of (+/-)r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene and (+/-) benzo(a)pyrene-4,5-oxide.
作者信息
Rojas M, Alexandrov K
机构信息
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.
出版信息
J Cancer Res Clin Oncol. 1988;114(1):110-2. doi: 10.1007/BF00390496.
Abstract
Mice and rats were treated topically with the BP metabolites, anti-BPDE and BPO. Rat epidermal DNA was extensively modified by BPO, while mouse epidermal DNA was preferentially modified by anti-BPDE. Anti-BPDE-dGuo adducts were observed only in mouse dermal DNA. DNA adducts were absent from the rat dermis. This adduct formation could be the reason for the very different in vivo biological effects of BP metabolites in the two species.
摘要
用BP代谢物、抗BPDE和BPO对小鼠和大鼠进行局部处理。BPO可使大鼠表皮DNA发生广泛修饰，而小鼠表皮DNA则优先被抗BPDE修饰。仅在小鼠真皮DNA中观察到抗BPDE-dGuo加合物。大鼠真皮中未出现DNA加合物。这种加合物的形成可能是这两种物种中BP代谢物体内生物学效应差异极大的原因。
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In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.在暴露于（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘和（±）-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并[a]芘的小鼠和大鼠皮肤中DNA加合物的体内形成和持久性。
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