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局部应用（±）r-7，t-8-二羟基-t-9，10-环氧-7，8，9，10-四氢苯并（a）芘和（±）苯并（a）芘-4，5-氧化物后小鼠和大鼠表皮与真皮中DNA加合物的比较。

Comparison of DNA adducts in mouse and rat epidermis versus dermis after topical application of (+/-)r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene and (+/-) benzo(a)pyrene-4,5-oxide.

作者信息

Rojas M, Alexandrov K

机构信息

Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.

出版信息

J Cancer Res Clin Oncol. 1988;114(1):110-2. doi: 10.1007/BF00390496.

DOI:10.1007/BF00390496
PMID:3127397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12243835/
Abstract

Mice and rats were treated topically with the BP metabolites, anti-BPDE and BPO. Rat epidermal DNA was extensively modified by BPO, while mouse epidermal DNA was preferentially modified by anti-BPDE. Anti-BPDE-dGuo adducts were observed only in mouse dermal DNA. DNA adducts were absent from the rat dermis. This adduct formation could be the reason for the very different in vivo biological effects of BP metabolites in the two species.

摘要

用BP代谢物、抗BPDE和BPO对小鼠和大鼠进行局部处理。BPO可使大鼠表皮DNA发生广泛修饰，而小鼠表皮DNA则优先被抗BPDE修饰。仅在小鼠真皮DNA中观察到抗BPDE-dGuo加合物。大鼠真皮中未出现DNA加合物。这种加合物的形成可能是这两种物种中BP代谢物体内生物学效应差异极大的原因。

相似文献

1
Comparison of DNA adducts in mouse and rat epidermis versus dermis after topical application of (+/-)r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene and (+/-) benzo(a)pyrene-4,5-oxide.局部应用（±）r-7，t-8-二羟基-t-9，10-环氧-7，8，9，10-四氢苯并（a）芘和（±）苯并（a）芘-4，5-氧化物后小鼠和大鼠表皮与真皮中DNA加合物的比较。
J Cancer Res Clin Oncol. 1988;114(1):110-2. doi: 10.1007/BF00390496.
2
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.在暴露于（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘和（±）-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并[a]芘的小鼠和大鼠皮肤中DNA加合物的体内形成和持久性。
Carcinogenesis. 1986 Sep;7(9):1553-60. doi: 10.1093/carcin/7.9.1553.
3
Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin.用苯并[a]芘二醇环氧化物及其相应氯醇对小鼠和大鼠皮肤进行离体处理后，表皮中反式和顺式DNA加合物的浓度。
Mutat Res. 2001 Jul 1;478(1-2):199-206. doi: 10.1016/s0027-5107(01)00153-1.
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Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.（+）-7,8-二羟基-7,8-二氢苯并（a）芘在小鼠皮肤中的过氧自由基和细胞色素P-450依赖性代谢激活：体外和体内研究
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6
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Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.局部应用的苯并(a)芘、反式-7,8-二羟基-7,8-二氢苯并(a)芘和7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并(a)芘在小鼠表皮中的体内处置和代谢对比。
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Immunohistochemical detection of anti-(+/-)-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)p yrene-bound adduct in nuclei of cultured HeLa cells and mouse lung tissue.免疫组织化学检测培养的HeLa细胞核及小鼠肺组织中抗-（+/-）-反式-7,8-二羟基-9,10-环氧-7,8,9,10-四氢苯并（a）芘结合加合物。
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Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of SENCAR mice following topical application of crude coal tar.局部涂抹粗煤焦油后，SENCAR小鼠表皮和肺中苯并(a)芘二醇环氧化物-I-DNA加合物的形成。
Cancer Lett. 1986 Dec;33(3):287-94. doi: 10.1016/0304-3835(86)90068-6.

本文引用的文献

1
Fifty years of benzo(a)pyrene.苯并(a)芘的五十年。
Nature. 1983;303(5917):468-72. doi: 10.1038/303468a0.
2
In vivo formation and persistence of DNA and protein adducts in mouse and rat skin exposed to (+/-)benzo[a]pyrene-4,5-oxide.
Carcinogenesis. 1986 Feb;7(2):235-40. doi: 10.1093/carcin/7.2.235.
3
Comparison of benzo[a]pyrene-DNA adduct levels in mouse and rat epidermis and dermis.小鼠和大鼠表皮及真皮中苯并[a]芘-DNA加合物水平的比较。
Cancer Lett. 1986 Jan;30(1):35-9. doi: 10.1016/0304-3835(86)90129-1.
4
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.在暴露于（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘和（±）-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并[a]芘的小鼠和大鼠皮肤中DNA加合物的体内形成和持久性。
Carcinogenesis. 1986 Sep;7(9):1553-60. doi: 10.1093/carcin/7.9.1553.
5
Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.苯并[a]芘4,5-、7,8-和9,10-氧化物对小鼠皮肤的致癌性。
Proc Natl Acad Sci U S A. 1976 Jan;73(1):243-7. doi: 10.1073/pnas.73.1.243.
6
Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.苯并(a)芘4,5-、7,5-和7,8-二醇-9,10-环氧化物以及7,8-二醇的皮肤肿瘤起始能力。
Cancer Lett. 1976 Nov;2(2):115-21. doi: 10.1016/s0304-3835(76)80020-1.
7
The reaction of (+/-)-7alpha, 8beta-dihydroxy-9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA.（±）-7α，8β-二羟基-9β，10β-环氧-7,8,9,10-四氢苯并（a）芘与DNA的反应
Int J Cancer. 1976 Sep 15;18(3):362-8. doi: 10.1002/ijc.2910180315.
8
Double-stranded DNA steroselectively binds benzo(a)pyrene diol epoxides.双链DNA对苯并(a)芘二醇环氧化物具有立体选择性结合作用。
Nature. 1979 Feb 1;277(5695):410-2. doi: 10.1038/277410a0.