Rojas M, Baer-Dubowska W, Alexandrov K
Cancer Lett. 1986 Jan;30(1):35-9. doi: 10.1016/0304-3835(86)90129-1.
Male Swiss mice and Wistar rats were treated topically with 250 nmol/mouse and 750 nmol/rat of [3H]benzo[a]pyrene ([3H]BaP). The initial level of total BaP--DNA and the individual modified deoxyribonucleoside adducts were similar in the skin epidermis of the two species. The concentration of these adducts was approximately 3 times less in both mouse and rat dermis. The decreased amount of BaP bound to DNA of mouse dermis may be related to the resistance of this tissue to the carcinogenic action of BaP. The ability of both the mouse (susceptible) and rat (resistant) skin to form BaP-bound products similar in nature and ratio in the epidermal and dermal DNA, suggests that other mechanisms are involved in the difference in the biological response of epidermis versus dermis to the carcinogenic effect of BaP.
对雄性瑞士小鼠和Wistar大鼠进行局部处理，分别给予每只小鼠250 nmol和每只大鼠750 nmol的[³H]苯并[a]芘（[³H]BaP）。两种动物皮肤表皮中总BaP-DNA的初始水平以及各个修饰的脱氧核糖核苷加合物相似。在小鼠和大鼠的真皮中，这些加合物的浓度均约低3倍。小鼠真皮中与DNA结合的BaP量减少可能与该组织对BaP致癌作用的抗性有关。小鼠（敏感）和大鼠（抗性）皮肤在表皮和真皮DNA中形成性质和比例相似的BaP结合产物的能力，表明表皮与真皮对BaP致癌作用的生物学反应差异涉及其他机制。
