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苯并(a)芘4,5-、7,5-和7,8-二醇-9,10-环氧化物以及7,8-二醇的皮肤肿瘤起始能力。

Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.

作者信息

Slaga T J, Viaje A, Betty D L, Brachen W, Buty S G, Scribner J D

出版信息

Cancer Lett. 1976 Nov;2(2):115-21. doi: 10.1016/s0304-3835(76)80020-1.

DOI:10.1016/s0304-3835(76)80020-1
PMID:1016959
Abstract

The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

摘要

利用两阶段肿瘤发生系统在小鼠中测定了苯并(a)芘（BP）的K区和非K区环氧化物的皮肤肿瘤引发能力。发现BP - 4,5 - 环氧化物和BP - 7,8 - 二氢二醇 - 9,10 - 环氧化物（反式）是弱肿瘤引发剂，而BP - 7,8 - 环氧化物的活性约为母体碳氢化合物BP的三分之一。然而，发现BP的7,8 - 二氢二醇的效力与BP大致相同，这表明它可能是一种直接致癌物。

相似文献

1
Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.苯并(a)芘4,5-、7,5-和7,8-二醇-9,10-环氧化物以及7,8-二醇的皮肤肿瘤起始能力。
Cancer Lett. 1976 Nov;2(2):115-21. doi: 10.1016/s0304-3835(76)80020-1.
2
Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.苯并(a)芘-7,8-二醇-9,10-环氧化物（反式）在四氢呋喃中局部应用时的皮肤肿瘤起始能力。
Cancer Lett. 1977 Jul;3(1-2):23-30. doi: 10.1016/s0304-3835(77)93845-9.
3
Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.非对映体苯并(a)芘7,8-二醇-9,10-环氧化物的旋光对映体在皮肤肿瘤起始活性方面存在显著差异。
Cancer Res. 1979 Jan;39(1):67-71.
4
Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.苯并(a)芘二醇环氧化物的致癌性研究表明，(±)-反式-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并(a)芘是新生小鼠的一种最终致癌物。
Cancer Res. 1978 Feb;38(2):354-8.
5
Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides.苯并(a)芘芳烃氧化物和二醇环氧化物的肿瘤起始活性比较。
Cancer Res. 1977 Nov;37(11):4130-3.
6
Epidermal hyperplasia after topical application of benzo (a) pyrene, benzo (a) pyrene diol epoxides, and other metabolites.局部应用苯并（a）芘、苯并（a）芘二醇环氧化物及其他代谢产物后出现的表皮增生。
Cancer Res. 1977 Apr;37(4):984-90.
7
Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin.苯并(a)芘的苯环衍生物对小鼠皮肤的致癌性。
Cancer Res. 1977 Sep;37(9):3356-61.
8
Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin.甲基化苯并(a)芘衍生物在小鼠皮肤中的肿瘤起始活性比较
Cancer Res. 1980 Apr;40(4):1073-6.
9
Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.苯并(a)芘苯环环氧化物的致突变性和细胞毒性。
Cancer Res. 1976 Sep;36(9 pt.1):3358-66.
10
Effect of trichloropropene oxide on the ability of polyaromatic hydrocarbons and their "K-region" oxides to initiate skin tumors in mice and to bind to DNA in vitro.三氯丙烯氧化物对多环芳烃及其“K区域”氧化物诱发小鼠皮肤肿瘤能力以及体外与DNA结合能力的影响。
J Natl Cancer Inst. 1977 Apr;58(4):1051-5. doi: 10.1093/jnci/58.4.1051.

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