在糖化血红蛋白（HbA1c）升高的肥胖非裔美国女性中，血清miR-17水平下调。
Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c.
作者信息
Williams Ariel, Dougal Dara Mc, Jenkins Willysha, Greene Natasha, Williams-DeVane Clarlynda, Kimbro K Sean
机构信息
1Julius l. Chambers Biomedical/ Biotechnology Research Institute, North Carolina Central University, 1801 Fayetteville St., 207 BBRI, Durham, NC 27707 USA.
2Department of Biomedical and Biologically Sciences, North Carolina Central University, 1801, St. Durham NC, Fayetteville, 27707 USA.
出版信息
J Diabetes Metab Disord. 2019 May 9;18(1):173-179. doi: 10.1007/s40200-019-00404-3. eCollection 2019 Jun.
PURPOSE
Type 2 diabetes is heterogeneous disease characterized by several conditions including hyperglycemia. It is estimated that over 350 million people worldwide are suffering from type 2 diabetes and this number is expected to rise. According to the CDC, African Americans were observed to have a 40% higher incidence of diabetes compared to European Americans. Epigenetic modulating mechanisms such as microRNAs (miRNAs), have recently been established as a massive regulatory machine in metabolic syndrome, obesity and type 2 diabetes. In the present study, we aimed to investigate the serum levels of circulating miRNA 17 (miR-17) of obese, African American women with elevated HbA.
METHODS
We investigated miR-17 serum levels using qPCR. Then we used Pairwise Pearson Correlation Test to determine the relationship between clinical metabolic parameters and miR-17 serum levels.
RESULTS
The results indicated that participants with elevated HbA exhibited a down regulation of serum miR-17 levels compared to participants with normal HbA. MiR-17 was also correlated with serum calcium in participants with normal HbA.
CONCLUSIONS
The results suggest that serum miR-17 is involved in the regulation of glucose and calcium homeostasis, which may contribute to the development of type 2 diabetes.
目的
2型糖尿病是一种异质性疾病，其特征包括多种情况，如高血糖。据估计，全球超过3.5亿人患有2型糖尿病，且这一数字预计还会上升。根据美国疾病控制与预防中心的数据，与欧洲裔美国人相比，非裔美国人患糖尿病的发病率高出40%。表观遗传调控机制，如微小RNA（miRNA），最近已被确立为代谢综合征、肥胖症和2型糖尿病中的一种重要调控机制。在本研究中，我们旨在调查血红蛋白A（HbA）升高的肥胖非裔美国女性的循环miRNA 17（miR-17）的血清水平。
方法
我们使用定量聚合酶链反应（qPCR）来检测miR-17的血清水平。然后我们使用成对皮尔逊相关检验来确定临床代谢参数与miR-17血清水平之间的关系。
结果
结果表明，与HbA正常的参与者相比，HbA升高的参与者血清miR-17水平下调。在HbA正常的参与者中，miR-17也与血清钙相关。
结论
结果表明血清miR-17参与葡萄糖和钙稳态的调节，这可能有助于2型糖尿病的发展。
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