基于金纳米壳的系统实现胃癌的光热和基因治疗联合免疫治疗。
Photothermal and gene therapy combined with immunotherapy to gastric cancer by the gold nanoshell-based system.
机构信息
Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, No. 126 XianTai Street, Changchun, 130033, Jilin, China.
Department of Endoscopic Center, China-Japan Union Hospital of Jilin University, No. 126 XianTai Street, Changchun, 130033, Jilin, China.
出版信息
J Nanobiotechnology. 2019 Jul 5;17(1):80. doi: 10.1186/s12951-019-0515-x.
BACKGROUND
The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic effect in clinical. However, the drug resistance problem limits its application.
METHOD
In this study, we develop a gold nanoshell (Gold Nanoshell) drug carrier for delivery and selective photo-thermal release of genes which target HER-2 and immunologic adjuvant CPG sequence in gastric tumor cells. The drug delivery system generated a multidimensional treatment strategy which includes gene-, immune- and photothermal-therapy.
RESULTS
The whole gold nanoshell drug delivery system exhibits the well gene transduction ability and combined treatment effect. Both in vitro and in vivo results demonstrate the multiple therapeutic effects of the drug delivery system is better than the monotherapy.
CONCLUSIONS
This study indicates the multiple combined therapy based on the gold nanoshell system would be a promising translational treatment for gastric cancer.
背景
胃癌是全球第二大恶性肿瘤。HER-2 是胃癌治疗的关键靶点之一。曲妥珠单抗等抗 HER-2 抗体在临床上显示出满意的疗效。然而，耐药问题限制了其应用。
方法
本研究构建了一种金纳米壳（Gold Nanoshell）药物载体，用于在胃癌细胞中递送和选择性光热释放靶向 HER-2 的基因和免疫佐剂 CPG 序列。该药物输送系统产生了一种多维治疗策略，包括基因、免疫和光热治疗。
结果
整个金纳米壳药物输送系统表现出良好的基因转导能力和联合治疗效果。体外和体内结果均表明，药物输送系统的多种治疗效果优于单一疗法。
结论
本研究表明，基于金纳米壳系统的多种联合治疗可能是一种有前途的胃癌转化治疗方法。
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