Kraft L M, Kelly M A, Johnson J E, Benton E V, Henke R P, Cassou R, Haymaker W, Philpott D E, Vogel F S, Zeman W
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Jan;35(1):33-61. doi: 10.1080/09553007914550041.
A study was made of tissues from 130 pocket mice after a single head-only exposure to high-LET 20Ne particle radiation at 1000, 100 or 10 rad (nominal surface dose) with the view of obtaining base"line data regarding the effectiveness of HZE (cosmic-ray) particles during spaceflight. First seen at 2-3 weeks after exposure, necrotic neurons in the cerebrum reached peak incidence (0 . 04 per cent at 1000 rad, 0 . 003 per cent at 100 rad and less than 0 . 0005 per cent at 10 rad) after 4-5 weeks and decreased to low levels thereafter. Incidence in the cerebellum was lower. Neuroglia, cells of the subependymal matrix and dentate gyrus precursor cells suffered acute damage at 1000 and at 100 rad. At 1000 rad, enlarged hyperchromatic neuroglia, first noted at 3 weeks, increased in number up to 7 months, then declined. Alterations in the retina and olfactory epithelium were seen at 1000 rad, and reaction in the scalp at 100 rad. Damage was incurred by dentinoblasts at 10 rad. Changes similar to those observed in pocket mice were found in the brains of gerbils and C57B1 mice.
对130只灌丛小鼠的组织进行了研究，这些小鼠头部单次暴露于高传能线密度（LET）的20Ne粒子辐射下，辐射剂量分别为1000、100或10拉德（标称表面剂量），目的是获取关于太空飞行期间HZE（宇宙射线）粒子有效性的基线数据。在暴露后2 - 3周首次观察到，大脑中的坏死神经元在4 - 5周后达到最高发生率（1000拉德时为0.04%，100拉德时为0.003%，10拉德时低于0.0005%），此后降至低水平。小脑的发生率较低。神经胶质细胞、室管膜下基质细胞和齿状回前体细胞在1000拉德和100拉德时遭受急性损伤。在1000拉德时，3周时首次发现的增大的深色神经胶质细胞数量在7个月内增加，然后减少。在1000拉德时可见视网膜和嗅上皮的改变，在100拉德时可见头皮的反应。在10拉德时，成牙本质细胞受到损伤。在沙鼠和C57B1小鼠的大脑中发现了与灌丛小鼠中观察到的类似变化。
