Inoue Shintaro, Katayama Ichiro, Suzuki Tamio, Tanemura Atsushi, Ito Shosuke, Abe Yuko, Sumikawa Yasuyuki, Yoshikawa Momoko, Suzuki Kayoko, Yagami Akiko, Masui Yukiko, Ito Akiko, Matsunaga Kayoko
Department of Cosmetic Health Science, Gifu Pharmaceutical University, Gifu, Japan.
Department of Pigmentation Research and Therapeutics, Osaka City University, Osaka, Japan.
J Dermatol. 2021 Jul;48(7):969-978. doi: 10.1111/1346-8138.15878. Epub 2021 May 5.
A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol-induced leukoderma based on data from original or review articles published in the literature to provide a wide range of information regarding the pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments. We compile and discuss the latest information, including data related to the cytotoxicity of rhododendrol, cytoprotective functions, and involvement of the immune system, and consider the possibility of novel treatments based on the differences between individual patients and on the mechanism underlying the onset of the condition. Understanding the pathophysiology of rhododendrol-induced leukoderma helps not only elucidate the mechanisms of non-segmental vitiligo onset and progression, but also suggests prevention and treatment.
一小部分使用含杜鹃醇化妆品的人出现了伴有各种病理状况的白斑病，在某些情况下与白癜风难以区分。在本综述中，我们基于文献中发表的原始文章或综述文章的数据，对杜鹃醇诱发白斑病的主要考量因素进行调查和评估，以提供有关病理生理学、机制、风险评估以及基于可能机制的治疗等方面的广泛信息。我们汇编并讨论了最新信息，包括与杜鹃醇细胞毒性、细胞保护功能以及免疫系统参与相关的数据，并基于个体患者之间的差异以及病情发作的潜在机制考虑新治疗方法的可能性。了解杜鹃醇诱发白斑病的病理生理学不仅有助于阐明非节段性白癜风的发病和进展机制，还能为预防和治疗提供思路。
