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休克指数在创伤性骨盆骨折中的预后作用:回顾性分析。

Prognostic Role of Shock Index in Traumatic Pelvic Fracture: A Retrospective Analysis.

机构信息

Department of Surgery, Clinical Research, Trauma & Vascular Surgery, Hamad General Hospital, Doha, Qatar; Department of Clinical Medicine, Weill Cornell Medical School, Doha, Qatar.

Department of Surgery, Trauma Surgery, Hamad General Hospital, Doha, Qatar.

出版信息

J Surg Res. 2019 Nov;243:410-418. doi: 10.1016/j.jss.2019.05.062. Epub 2019 Jul 3.

Abstract

BACKGROUND

We aimed to validate the utility of shock index (SI) in predicting the need of blood transfusion and outcomes in patients with traumatic pelvic fracture (TPF).

MATERIALS AND METHODS

We conducted a retrospective analysis for patients who sustained TPF between 2012 and 2016 in a level 1 trauma center. Patients were categorized into patients with low versus high SI based on the cutoff obtained from the receiver operating characteristic curves to predict mortality.

RESULTS

A total of 966 patients sustained TPF (28.5% had SI ≥ 0.9 based on receiver operating characteristic curves) with a median age of 33 (IQR 25-47) y. Type B and C pelvic fractures significantly had higher SI. The frequency of blood transfusion use was greater in patients with high SI (P = 0.001). SI correlated significantly with Injury Severity Score (r = 0.32), Revised Trauma Score (r = -0.40), and transfused blood units (r = 0.35). Patients with high SI had prolonged hospital length of stay and higher mortality (P = 0.001). SI ≥ 0.9 showed high sensitivity and negative predictive value to identify the need of massive blood transfusion (77% and 86%, respectively) and mortality (73.5% and 98.1%, respectively). For hospital mortality, high SI had a sensitivity of 73.5%, specificity 74%, negative predictive value 98%, and negative likelihood ratio of 0.36. After adjustment for age, sex, Injury Severity Score, Glasgow Coma Scale, pelvis Abbreviated Injury Scale, blood transfusion, and Tile classification, the multivariate analysis models showed that high SI was an independent predictor of blood transfusion (odd ratio 5.6) and mortality (odd ratio 3.63).

CONCLUSIONS

SI is a potentially useful instant tool for the prediction of massive transfusion and mortality in patients with TPF. Further prospective studies are warranted to support our findings.

摘要

背景

本研究旨在验证休克指数(SI)在预测创伤性骨盆骨折(TPF)患者输血需求和结局方面的作用。

材料与方法

我们对 2012 年至 2016 年期间在一家 1 级创伤中心接受治疗的 TPF 患者进行了回顾性分析。患者根据受试者工作特征曲线(ROC)获得的截断值分为低休克指数(SI)组和高休克指数(SI)组,以预测死亡率。

结果

共纳入 966 例 TPF 患者(28.5%的患者根据 ROC 获得的截断值具有 SI≥0.9),患者的中位年龄为 33(IQR 25-47)岁。B 型和 C 型骨盆骨折的 SI 明显更高。高 SI 组患者输血的频率更高(P=0.001)。SI 与损伤严重程度评分(r=0.32)、修订创伤评分(r=-0.40)和输血量(r=0.35)显著相关。高 SI 患者的住院时间延长,死亡率更高(P=0.001)。SI≥0.9 对识别大量输血(分别为 77%和 86%)和死亡率(分别为 73.5%和 98.1%)的敏感性和阴性预测值均较高。对于院内死亡率,高 SI 的敏感性为 73.5%,特异性为 74%,阴性预测值为 98%,负似然比为 0.36。在校正年龄、性别、损伤严重程度评分、格拉斯哥昏迷评分、骨盆损伤严重程度评分、输血和Tile 分类后,多变量分析模型显示高 SI 是输血(比值比 5.6)和死亡率(比值比 3.63)的独立预测因素。

结论

SI 是预测 TPF 患者大量输血和死亡率的一种潜在有用的即时工具。需要进一步的前瞻性研究来支持我们的发现。

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